A thermodynamic study of F108 and F127 block copolymer interactions with liposomes at physiological temperature

Solis-Gonzalez, Obed Andres; Avendaño-Gómez, Juan Ramon; Rojas-Aguilar, Aarón

doi:10.1080/08982104.2020.1865401

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…At 1 mM, the enthalpy of micellization (ΔH mic ) of neat F127 is about 280 kJ/mol (Figure 4a), in agreement with previous publications (Bouchemal et al, 2009;Oliveira et al, 2020;Solis-Gonzalez et al, 2021), while in presence of DODAC, it is smaller, about 250 kJ/mol. Above this concentration, ΔH mic is even higher, probably due formation of more complex micellar structures.…”

Section: Dodac/f127 Aqueous Systemsupporting

confidence: 91%

“…The borders between these stages indicate stronger effects of lipid chain length than of the counterion because of the more pronounced border variation for DDAB (same counterion but shorter chains) than for DODAC (same chain lengths but different counterions) relative to DODAB (Figure 6). Based on previous studies on lipid-Pluronic aqueous systems (Bouchemal et al, 2009;Chieng & Chen, 2009;Solis-Gonzalez et al, 2021), hydrophobic and entropic interactions might be the driving forces involved in the CL-F127 molecular complexation and, therefore, in the vesicle-to-micelle transition. The CL/F127 mixed structures (vesicles or micelles) can be suitable as nonviral vectors in gene therapy.…”

Section: Discussionmentioning

confidence: 99%

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Vesicle‐to‐micelle transition in aqueous mixtures of cationic lipids with Pluronic F127

Feitosa

Lemos

Adati

2023

J Surfact & Detergents

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Aqueous solutions of vesicle‐forming lipids mixed with micelle‐forming copolymers may result in stabilized and biocompatible aggregates. Differential scanning calorimetry (DSC) and dynamic light scattering (DLS) techniques were used here to investigate the effects of the nonionic triblock copolymer Pluronic F127 (F127) on the thermal behavior, structural changes, and hydrodynamic size of cationic vesicles from dioctadecyldimethylammonium chloride (DODAC), dioctadecyldimethylammonium bromide (DODAB), and didodecyldimethylammonium bromide (DDAB) in aqueous dispersion. The DSC thermograms indicate that upon the addition of up to 5.0 mM F127, a vesicle‐to‐micelle transition occurs in three stages. First, there is a predominance of lipid‐F127 mixed vesicles, followed by the co‐existence of mixed vesicles and micelles, and finally, the system is dominated by mixed micelles. DLS results reveal that with the addition of F127 to the lipid dispersions, the size of the assembled structures tends to decrease, also indicating structural changes of vesicles to micelles. These results indicate that the borders between these stages depend on the lipid chain length and counterion type.

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Section: Dodac/f127 Aqueous Systemsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Vesicle‐to‐micelle transition in aqueous mixtures of cationic lipids with Pluronic F127

Feitosa

Lemos

Adati

2023

J Surfact & Detergents

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“…The ultrasonic velocity, dynamic scattering, light scattering, small-angle X-ray diffraction, small-angle neutron scattering, rheology and electrolyte behavior of the P407 aqueous solution were studied [ 26 , 27 , 28 , 29 ]. It was found that the gelation process was the result of micellar properties (aggregation number and micellar symmetry, etc.)…”

Section: Discussionmentioning

confidence: 99%

Preparation, Properties and Therapeutic Effect of a TPL Nanoparticle Thermosensitive Gel for Intra-Articular Injection

et al. 2023

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Most injectable preparations for the articular cavity are solution-type preparations that are frequently administered because of rapid elimination. In this study, triptolide (TPL), an effective ingredient in the treatment of rheumatoid arthritis (RA), was prepared in the form of a nanoparticle thermosensitive gel (TPL-NS-Gel). The particle size distribution and gel structure were investigated by TEM, laser particle size analysis and laser capture microdissection. The effect of the nanoparticle carrier material PLGA on the phase transition temperature was investigated by 1H variable temperature NMR and DSC. The tissue distribution, pharmacokinetic behavior, four inflammatory factors and therapeutic effect were determined in a rat RA model. The results suggested that PLGA increased the gel phase transition temperature. The drug concentration of the TPL-NS-Gel group in joint tissues was higher than that in other tissues at different time points, and the retention time was longer than that of the TPL-NS group. After 24 days of administration, TPL-NS-Gel significantly improved the joint swelling and stiffness of the rat models, and the improvement degree was better than that of the TPL-NS group. TPL-NS-Gel significantly decreased the levels of hs-CRP, IL-1, IL-6 and TNF-α in serum and joint fluid. There was a significant difference between the TPL-NS-Gel and TPL-NS groups on Day 24 (p < 0.05). Pathological section results showed that inflammatory cell infiltration was lower in the TPL-NS-Gel group, and no other obvious histological changes were observed. Upon articular injection, the TPL-NS-Gel prolonged drug release, reduced the drug concentration outside the articular tissue and improved the therapeutic effect in a rat RA model. The TPL-NS-Gel can be used as a new type of sustained-release preparation for articular injection.

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A thermodynamic study of F108 and F127 block copolymer interactions with liposomes at physiological temperature

Cited by 2 publications

References 39 publications

Vesicle‐to‐micelle transition in aqueous mixtures of cationic lipids with Pluronic F127

Vesicle‐to‐micelle transition in aqueous mixtures of cationic lipids with Pluronic F127

Preparation, Properties and Therapeutic Effect of a TPL Nanoparticle Thermosensitive Gel for Intra-Articular Injection

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