A thermodynamic analysis of the binding interaction between polysorbate 20 and 80 with human serum albumins and immunoglobulins: A contribution to understand colloidal protein stabilisation

Key interactions of surfactants in therapeutic protein formulations: A review

“…The [64]. The presence of surfactant is also not expected to impact the pharmacokinetic parameters associated with biologics, especially in the case for mAbs dominated by…”

Adsorption behavior of a human monoclonal antibody at hydrophilic and hydrophobic surfaces

“…These calorimetry results are consistent with previous reports for titration of polysorbate against three other mAbs and albumin in solution. 28 Loss of protein at the solid/liquid interface is also an important consideration and may be particularly relevant during dilution and administration that involve use of plastic bags and intravenous lines. 15 Adsorption of mAbs to glass vials has been shown to be due predominantly to electrostatic interactions.…”

Stability of Protein Pharmaceuticals: An Update

“…Since those first reports, polysorbates have been found to bind to fusion proteins as well (405). It is also worth noting that there have been reports of polysorbates not binding to certain proteins, especially antibodies (406,407). Pluronic F-107, another nonionic surfactant, has been found to bind to G-CSF (408).…”