2023
DOI: 10.1002/jex2.109
|View full text |Cite|
|
Sign up to set email alerts
|

A thermo‐resistant and RNase‐sensitive cargo from Giardia duodenalis extracellular vesicles modifies the behaviour of enterobacteria

Affan Siddiq,
George Dong,
Balu Balan
et al.

Abstract: Extracellular vesicles (EVs) recently emerged as important players in the pathophysiology of parasitic infections. While the protist parasite Giardia duodenalis can produce EVs, their role in giardiasis remains obscure. Giardia can disrupt gut microbiota biofilms and transform commensal bacteria into invasive pathobionts at sites devoid of colonizing trophozoites via unknown mechanisms. We hypothesized that Giardia EVs could modify gut bacterial behaviour via a novel mode of trans‐kingdom communication. Our fi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2
1

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(1 citation statement)
references
References 81 publications
0
1
0
Order By: Relevance
“…Distinct EVs have been reported in most groups of parasitic protozoa, including flagellates [46] and sporozoa [47]. Recently, the release and characterization of EVs from Giardia have been described [26], and they have been implicated in host-pathogen interactions [24,48,49]. Giardia EVs contain besides DNA or RNA, lipids and important proteins involved in the survival of the parasite and in regulating the infection including VSPs, HSP70, β-tubulin, α tubulin, giardin, ADI, OCT, enolase, proteases [50,51].…”
Section: Discussionmentioning
confidence: 99%
“…Distinct EVs have been reported in most groups of parasitic protozoa, including flagellates [46] and sporozoa [47]. Recently, the release and characterization of EVs from Giardia have been described [26], and they have been implicated in host-pathogen interactions [24,48,49]. Giardia EVs contain besides DNA or RNA, lipids and important proteins involved in the survival of the parasite and in regulating the infection including VSPs, HSP70, β-tubulin, α tubulin, giardin, ADI, OCT, enolase, proteases [50,51].…”
Section: Discussionmentioning
confidence: 99%