A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase

Abstract

For centuries, phytochemicals have been used to prevent and cure multiple health ailments. Phytochemicals have been reported to have antioxidant, antidiabetic, antitussive, antiparasitic, anticancer, and antimicrobial properties. Generally, the therapeutic use of phy-tochemicals is based on tradition or word of mouth with few evidence-based studies. Moreo-ver, molecular level interactions or molecular targets for the majority of phytochemicals are unknown. In recent years, antibiotic resistance by microbes has become a major healthcare concern. As such, the use of phytochemicals with antimicrobial properties has become perti-nent. Natural compounds from plants, vegetables, herbs, and spices with strong antimicrobial properties present an excellent opportunity for preventing and combating antibiotic resistant microbial infections. ATP synthase is the fundamental means of cellular energy. Inhibition of ATP synthase may deprive cells of required energy leading to cell death, and a variety of die-tary phytochemicals are known to inhibit ATP synthase. Structural modifications of phyto-chemicals have been shown to increase the inhibitory potency and extent of inhibition. Site-directed mutagenic analysis has elucidated the binding site(s) for some phytochemicals on ATP synthase. Amino acid variations in and around the phytochemical binding sites can re-sult in selective binding and inhibition of microbial ATP synthase. In this review, the therapeu-tic connection between dietary phytochemicals and ATP synthase is summarized based on the inhibition of ATP synthase by dietary phytochemicals. Research suggests selective target-ing of ATP synthase is a valuable alternative molecular level approach to combat antibiotic resistant microbial infections.

Effect of using acid whey for marinating chicken breast muscles in organic production

“…From the microbiological perspective, the antimicrobial substances contained in acid whey and lemon juice, such as organic acids, whey protein, bacteriocins and polyphenols, were responsible for the inhibition of microbial growth. The pH reduction caused by organic acids (citric, lactic) was the primary factor that affected the reduction of microorganisms (Ahmad et al, 2017;Alvadaro and Mc Kee 2007;Amini et al, 2017). In the present study it was shown that after thermal treatment no aerobic bacteria were found in both the control group and in WM and LJM.…”

Sulfonamides influence on the activity of thylakoid ATPase isolated from spinach chloroplasts

“…According to the results of this and previous works [7,8], we can state that sulfonamide compounds, known as carbonic anhydrase inhibitors, are able to modify the activity of the chloroplast ATPase, a multisubunits enzyme, which has several active and regulatory centers [10], and can be a useful tool when studying the features of the catalytic process in membrane ATP synthases of various origins. The data of this and previous works [7,8] show for the first time that some compounds of the sulfonamide class are agents aimed at ATP synthase, which cause growing interest during the development of new methods of treating human and animal diseases and agricultural applications [27,28]. Вивчалася дія двох водорозчинних сульфаніламідів ароматичного 4амінобензолсульфоніламіду (СА) і аліфатичного трифторметилсульфоніламіду (ТФМСА) на латентну і стимульовану АТРазну активність каталітичної частини тилакоїдної АТРсинтази, ізольованої з хлоропластів шпинату.…”

Corona virus versus existence of human on the earth: A computational and biophysical approach

“…The 6-helices or a 5-helices structure is used as a receptor for protein or peptide docking [39]. Scientists are also looking at molecules that could block furin, which could be investigated as possible therapies [41,[49][50][51].…”