In 2010, the Infusion Nurses Society began work to identify research priorities for infusion nursing. Nurses need to understand the research process and become proficient in collaboration to promote research in their specialty. One of the most important components of conducting research is the written research proposal. A poorly written proposal may result in denial of funding, rejected publications, and prolonged discussion and revision at the institutional or ethics review board. This article provides an overview of the elements needed in a research proposal, identifies institutional review board requirements, and highlights important criteria for recruitment and consent of subjects.