A theoretical study on entropy-driven polymer translocation through a finite-sized nanochannel

Prediction of the effective force on DNA in a nanopore based on density functional theory

“…[4][5][6] In the DNA translocation process, the drag forces opposing electrical driving force can be divided into three components: 7,8 (1) the entropic force of DNA uncoiling/recoiling at the pore entrance/exits; (2) the hydrodynamic drag on untranslocated blob-like part of the DNA molecule outside the pore; (3) the electro-osmotic force acting on the linear DNA inside nanopore. Meng et al 9 focused on pure entropy-driven transportation dynamics of a single polymer through a cylinder nanochannel. Storm et al 1 evaluated the hydrodynamic drag acting on the blob-like DNA conguration outside the nanopore based on experimental parameters.…”