A Theoretical Model of Oxygen Delivery and Metabolism for Physiologic Interpretation of Quantitative Cerebral Blood Flow and Metabolic Rate of Oxygen

Hayashi, Toshimitsu; Watabe, Hiroshi; Kudomi, Nobuyuki; Kim, Kyeong Min; Enmi, Jun Ichiro; Hayashida, Kentaro; Iida, Hidehiro

doi:10.1097/01.wcb.0000090506.76664.00

Cited by 65 publications

(99 citation statements)

References 40 publications

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“…In fact, Hattori et al (2004) recently showed that OEF values in three-step method were not identical to those in gOEF AÀV in human, suggesting the presence of physiologic change during the measurement. The present method may also make physiologic interpretations of flow and metabolism more accurate (Hayashi et al, 2003). Finally, it allows evaluation of coupling or uncoupling of CBF and CMRO 2 during functional activation or pharmacological stress, such as that induced by acetazolamide used for assessment of cerebral vascular reserves.…”

Section: Discussionmentioning

confidence: 97%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

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101

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Cerebral blood flow (CBF) and rate of oxygen metabolism (CMRO 2 ) may be quantified using positron emission tomography (PET) with 15 O-tracers, but the conventional three-step technique requires a relatively long study period, attributed to the need for separate acquisition for each of 15 O 2 , H 2 15 O, and C 15 O tracers, which makes the multiple measurements at different physiologic conditions difficult. In this study, we present a novel, faster technique that provides a pixel-by-pixel calculation of CBF and CMRO 2 from a single PET acquisition with a sequential administration of 15 O 2 and H 2 15 O. Experiments were performed on six anesthetized monkeys to validate this technique. The global CBF, oxygen extraction fraction (OEF), and CMRO 2 obtained by the present technique at rest were not significantly different from those obtained with three-step method. The global OEF (gOEF) also agreed with that determined by simultaneous arterio-sinus blood sampling (gOEF AÀV ) for a physiologically wide range when changing the arterial PaCO 2 (gOEF ¼ 1.03gOEF AÀV þ 0.01, Po0.001). The regional values, as well as the image quality were identical between the present technique and three-step method for CBF, OEF, and CMRO 2 . In addition, a simulation study showed that error sensitivity of the present technique to delay or dispersion of the input function, and the error in the partition coefficient was equivalent to that observed for three-step method. Error sensitivity to cerebral blood volume (CBV) was also identical to that in the three-step and reasonably small, suggesting that a single CBV assessment is sufficient for repeated measures of CBF/CMRO 2 . These results show that this fast technique has an ability for accurate assessment of CBF/CMRO 2 and also allows multiple assessment at different physiologic conditions.

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Section: Discussionmentioning

confidence: 97%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

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101

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“…A deeper question is to ask why n is not equal to 1, because this is the central phenomenon underlying the BOLD effect. This is an area of active research (Aubert and Costalat, 2002;Buxton, 2004;Buxton and Frank, 1997;Gjedde et al, 1991Gjedde et al, , 2002Hayashi et al, 2003;Hyder et al, 1998;Woo and Hathout, 2001;Zheng et al, 2002), and as this work is refined it can be included as a central step in modeling the path from stimulus to BOLD response.…”

Section: Modeling the Hemodynamic Responsementioning

confidence: 99%

Modeling the hemodynamic response to brain activation

et al. 2004

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Neural activity in the brain is accompanied by changes in cerebral blood flow (CBF) and blood oxygenation that are detectable with functional magnetic resonance imaging (fMRI) techniques. In this paper, recent mathematical models of this hemodynamic response are reviewed and integrated. Models are described for: (1) the blood oxygenation level dependent (BOLD) signal as a function of changes in cerebral oxygen extraction fraction (E) and cerebral blood volume (CBV); (2) the balloon model, proposed to describe the transient dynamics of CBV and deoxyhemoglobin (Hb) and how they affect the BOLD signal; (3) neurovascular coupling, relating the responses in CBF and cerebral metabolic rate of oxygen (CMRO 2 ) to the neural activity response; and (4) a simple model for the temporal nonlinearity of the neural response itself. These models are integrated into a mathematical framework describing the steps linking a stimulus to the measured BOLD and CBF responses. Experimental results examining transient features of the BOLD response (post-stimulus undershoot and initial dip), nonlinearities of the hemodynamic response, and the role of the physiologic baseline state in altering the BOLD signal are discussed in the context of the proposed models. Quantitative modeling of the hemodynamic response, when combined with experimental data measuring both the BOLD and CBF responses, makes possible a more specific and quantitative assessment of brain physiology than is possible with standard BOLD imaging alone. This approach has the potential to enhance numerous studies of brain function in development, health, and disease. D

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“…To achieve the ultimate goal of reconstructing neuronal activity from the haemodynamic responses measured, for example, via the fMRI signals (Buxton et al, 2004), it appears that current haemodynamic models have yet to be made more realistic physiologically (Hayashi et al, 2003;Fantini, 2002). For instance, usually only one vascular compartment is modeled, neglecting the fact that arteries, arterioles, capillaries, venules, and veins all have different responses.…”

Section: Implications For Modeling Cerebral Haemodynamics and Oxygen mentioning

confidence: 99%

Coupling between neuronal activity and microcirculation: Implications for functional brain imaging

Vanzetta

Grinvald

2008

HFSP Journal

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In the neocortex, neurons with similar response properties are often clustered together in column-like structures, giving rise to what has become known as functional architecture-the mapping of various stimulus feature dimensions onto the cortical sheet. At least partially, we owe this finding to the availability of several functional brain imaging techniques, both post-mortem and in-vivo, which have become available over the last two generations, revolutionizing neuroscience by yielding information about the spatial organization of active neurons in the brain. Here, we focus on how our understanding of such functional architecture is linked to the development of those functional imaging methodologies, especially to those that image neuronal activity indirectly, through metabolic or haemodynamic signals, rather than directly through measurement of electrical activity. Some of those approaches allow exploring functional architecture at higher spatial resolution than others. In particular, optical imaging of intrinsic signals reaches the striking detail of È50 m, and, together with other methodologies, it has allowed characterizing the metabolic and haemodynamic responses induced by sensory-evoked neuronal activity. Here, we review those findings about the spatio-temporal characteristics of neurovascular coupling and discuss their implications for functional brain imaging, including position emission tomography, and non-invasive neuroimaging techniques, such as funtional magnetic resonance imaging, applicable also to the human brain.

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A Theoretical Model of Oxygen Delivery and Metabolism for Physiologic Interpretation of Quantitative Cerebral Blood Flow and Metabolic Rate of Oxygen

Cited by 65 publications

References 40 publications

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Modeling the hemodynamic response to brain activation

Coupling between neuronal activity and microcirculation: Implications for functional brain imaging

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A Theoretical Model of Oxygen Delivery and Metabolism for Physiologic Interpretation of Quantitative Cerebral Blood Flow and Metabolic Rate of Oxygen

Cited by 65 publications

References 40 publications

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Modeling the hemodynamic response to brain activation

Coupling between neuronal activity and microcirculation: Implications for functional brain imaging

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Product

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Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys