A theoretical approach for quantifying the impact of changes in effective population size and expression level on the rate of coding sequence evolution
Abstract:Molecular sequences are shaped by selection, where the strength of selection relative to drift is determined by effective population size (Ne). Populations with high Ne are expected to undergo stronger purifying selection, and consequently to show a lower substitution rate for selected mutations relative to the substitution rate for neutral mutations (ω). However, computational models based on biophysics of protein stability have suggested that ω can also be independent of Ne, a result proven under general con… Show more
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