2020
DOI: 10.1101/2020.03.09.983809
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A TgfβRI/Snai1-dependent developmental module at the core of vertebrate axial elongation

Abstract: Formation of the vertebrate postcranial body axis follows two sequential but distinct phases. The first phase generates pre-sacral structures (the so-called primary body) through the activity of the primitive streak (PS) on axial progenitors within the epiblast. The embryo then switches to generate the secondary body (post-sacral structures), which depends on axial progenitors in the tail bud. Here we show that the mammalian tail bud is generated through an independent developmental module, concurrent but func… Show more

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Cited by 2 publications
(2 citation statements)
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“…The representative results shown in this paper for both the live and the immunofluorescence imaging, were obtained using a two-photon system, with a 20 × 1.0 NA water objective, the excitation laser tuned to 960 nm, and GaAsP photodetectors (as described in Dias et al (2020) 43 . Optical projection tomography was done using a custom built OPenT scanner (as described in Gualda et al (2013) 28 .…”
Section: Representative Resultsmentioning
confidence: 99%
“…The representative results shown in this paper for both the live and the immunofluorescence imaging, were obtained using a two-photon system, with a 20 × 1.0 NA water objective, the excitation laser tuned to 960 nm, and GaAsP photodetectors (as described in Dias et al (2020) 43 . Optical projection tomography was done using a custom built OPenT scanner (as described in Gualda et al (2013) 28 .…”
Section: Representative Resultsmentioning
confidence: 99%
“…One could say that the understanding of e.g. tailbud structure, embryonic heart development, and uterine architecture is almost immediate when shown, respectively, as in (Arora et al, 2016; Dias et al, 2020; Ivanovitch et al, 2017), even without the animated videos that may accompany such publications. Still, access to these models and thus the ability to explore them, is entirely dependent on the sharing practices of each individual set of authors, or of the venue of publication.…”
Section: Spatial Thinking In Developmental Biology: Understanding Andmentioning
confidence: 99%