A test to determine parameters of aerobic function during exercise

Whipp, Brian J.; Davis, James A.; Torres, F.; Wasserman, Karlman

doi:10.1152/jappl.1981.50.1.217

Cited by 562 publications

(424 citation statements)

References 0 publications

Supporting

Mentioning

396

Contrasting

Unclassified

Order By: Relevance

“…[12][13][14] An increase in anaerobic metabolism within the muscle cells in chronic heart failure has been demonstrated during static exercise by nuclear magnetic resonance spectroscopy. 11 An increase in ∆V…”

Section: Discussionmentioning

confidence: 99%

The Time From Anaerobic Threshold (AT) to Respiratory Compensation Point Reflects the Rate of Aerobic and Anaerobic Metabolism After the AT in Chronic Heart Failure Patients

et al. 1999

View full text Add to dashboard Cite

hen a subject performs incremental exercising testing, exercise hyperpnea increases toward the end of the exercise. This is due to an increase in acidosis, which is caused by accumulating lactic acid. 1 Lactic acid is produced once the working skeletal muscle cells reach the anaerobic threshold (AT). 2 Usually circulating bicarbonate compensates for this lactic acidosis to begin with. This period is called the isocapnic buffering stage. 3 However, beyond a certain point work intensity becomes so great that lactic acid production can no longer be compensated by circulating bicarbonate and hyperventilation begins. This point is called the respiratory compensation point (RCP). 2 We have previously reported that in heart failure the ability of skeletal muscle to uilize oxygen is increased during mild exercise by increasing the arteriovenous oxygen difference. 4 However, there are few reports of aerobic metabolism after AT. The time from AT to the RCP (RCP-AT time), ie, the duration of isocapnic buffering, varies from subject to subject, although the normal value is believed to be approximately 2 min. 3,5 RCP-AT time depends on the rate of aerobic and anaerobic metabolism after AT, and for subjects with reduced exercise tolerance, such as chronic heart failure patients, this period seems to be shorter. However, the significance of this period is not yet fully understood, and it has not been determined whether the duration of this period is correlated with any indicators of exercise tolerance, such as the anaerobic threshold.Thus, we studied the correlation between the RCP-AT time and the anaerobic threshold and also investigated the correlation between RCP-AT time and the ∆V • O2/∆WR, which is thought to indicate the peripheral blood flow and also the aerobic exercise tolerance. We hypothesized that RCP-AT time may be a new indicator that shows the rate of aerobic and anaerobic metabolism after the AT point. Methods Study PatientsWe studied 37 patients with chronic heart failure (19 men and 18 women); all patients were in New York Heart Association functional class II or III. Their diagnoses were dilated cardiomyopathy and coronary artery disease, and their mean age was 57.8±6.3 years. The nature and the purpose of the study and the risks involved were explained, and informed consent was obtained from each subject before his or her voluntary consent to entry into the study. Ventilatory ParametersPatients performed the cardiopulmonary exercise test under expired gas analysis. Expired gases were monitored continuously in all patients by a breath-by-breath expired gas analyzer (AE280S, Minato Ikagaku, Tokyo, Japan). Oxygen uptake (V • O2), carbon dioxide output (V • CO2), and minute ventilation (V • E) were measured. Anaerobic threshold (AT) was determined as the break point in the V-slope method. 1 The respiratory compensation point (RCP) was determined as the point at which the ratio of minute ventiJpn Circ J 1999; 63: 274 -277 (Received August 5, 1998; revised manuscript received December 24, 1998; accepted December...

show abstract

Section: Discussionmentioning

confidence: 99%

The Time From Anaerobic Threshold (AT) to Respiratory Compensation Point Reflects the Rate of Aerobic and Anaerobic Metabolism After the AT in Chronic Heart Failure Patients

et al. 1999

View full text Add to dashboard Cite

show abstract

“…The cardiopulmonary exercise test was done with a bicycle ergometer (Siemens Elema 380, Solna, Sweden) in the upright position until exhaustion [31]. The initial workload was 20 W with subsequent increments of 20 W/min.…”

Section: Methodsmentioning

confidence: 99%

Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults

et al. 2000

View full text Add to dashboard Cite

“…This is typically established by means of a progressive increase in work-rate by a small fixed increment at a fixed frequency (e.g. each minute or less), in a ''staircase'' fashion, or when work-rate is increased incrementally under computer control as a smooth continuous ramp both with cycle-ergometry [1,[3][4][5] and, more recently, for the treadmill [6]. However, high-intensity constant-load tests are also becoming widely used as, in many instances, they provide a sensitive discrimination of improved function consequent to an intervention.…”

mentioning

confidence: 99%

Recommendations on the use of exercise testing in clinical practice

Palange¹,

Ward²,

Carlsen³

et al. 2006

European Respiratory Journal

Self Cite

549

390

View full text Add to dashboard Cite

Evidence-based recommendations on the clinical use of cardiopulmonary exercise testing (CPET) in lung and heart disease are presented, with reference to the assessment of exercise intolerance, prognostic assessment and the evaluation of therapeutic interventions (e.g. drugs, supplemental oxygen, exercise training). A commonly used grading system for recommendations in evidence-based guidelines was applied, with the grade of recommendation ranging from A, the highest, to D, the lowest.For symptom-limited incremental exercise, CPET indices, such as peak O 2 uptake (V9O 2 ), V9O 2 at lactate threshold, the slope of the ventilation-CO 2 output relationship and the presence of arterial O 2 desaturation, have all been shown to have power in prognostic evaluation. In addition, for assessment of interventions, the tolerable duration of symptom-limited high-intensity constant-load exercise often provides greater sensitivity to discriminate change than the classical incremental test. Field-testing paradigms (e.g. timed and shuttle walking tests) also prove valuable.In turn, these considerations allow the resolution of practical questions that often confront the clinician, such as: 1) ''When should an evaluation of exercise intolerance be sought?''; 2) ''Which particular form of test should be asked for?''; and 3) ''What cluster of variables should be selected when evaluating prognosis for a particular disease or the effect of a particular intervention?''

show abstract

A test to determine parameters of aerobic function during exercise

Cited by 562 publications

References 0 publications

The Time From Anaerobic Threshold (AT) to Respiratory Compensation Point Reflects the Rate of Aerobic and Anaerobic Metabolism After the AT in Chronic Heart Failure Patients

The Time From Anaerobic Threshold (AT) to Respiratory Compensation Point Reflects the Rate of Aerobic and Anaerobic Metabolism After the AT in Chronic Heart Failure Patients

Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults

Recommendations on the use of exercise testing in clinical practice

Contact Info

Product

Resources

About