A Test of Connective Tissue State and Reactivity in Collagen Diseases*

Laskin, Daniel M.; Engel, Milton B.; Joseph, Norman R.; Pollak, Victor E.

doi:10.1172/jci104441

Cited by 8 publications

(2 citation statements)

References 18 publications

(37 reference statements)

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“…Such a block would explain some of the abnormalities of mucopolysaccharide metabolism in rheumatoid arthritis (7)(8)(9)(10). Of these, the one discovered by Laskin, Engel, Joseph, and Pollak (8) is intriguing because it proved reversible by the administration of glucocorticoid hormones.…”

Section: Discussionmentioning

confidence: 99%

“…The postulate that abnormal manganese metabolism might be present in human collagen disease rests on the following: (a) Rheumatoid arthritis displays abnormalities of mucoprotein and mucopolysaccharide metabolism (7)(8)(9)(10); (b) Another collagen disease, the hydralazine syndrome, appeared linked to manganese deficiency on the basis of animal studies (11,12) ; (c) Induction of the hydralazine syndrome seems to depend upon the genetic substratum (13); and (d) Genetic factors may interact with environmental ones in the development of manganese deficiency, as was proven by the manganese-dependent defects of the pallid strain of mice (14,15).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Slow turnover of manganese in active rheumatoid arthritis accelerated by prednisone

Cotzias¹,

Papavasiliou²,

Hughes³

et al. 1968

J. Clin. Invest.

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Total body and area counts of intravenously injected 54Mn were measured periodically in 29 in-patients. A heterogeneous group of 19 control patients showed fair reproducibility in the immediate distribution, and considerable individual variance in the subsequent loss of the isotope. Eight studies of the effects of feeding excesses of manganous sulfate to five patients showed acceleration of the rate of loss of the radioisotope from the whole body and the liver. These findings seem compatible with the presence of control mechanisms in man, operating to vary the metal's excretion, while tending to preserve constancy of its concentration in tissues.Slow turnover rates of the metal were demonstrated in seven out of eight patients with active rheumatoid arthritis, in one with hydralazine disease, but not in one arthritic undergoing an impressive, spontaneous remission. Statistically significant differences were encountered in the measurements of 54Mn turnover of the total body, the thyroid, and the liver.Administration of prednisone induced clinical improvement and significant acceleration of these turnovers. Slow turnovers are characteristic of nutritional manganese deficiency. Therefore, serum and blood manganese determinations were performed by neutron activation analysis on 14 control patients, and on six patients with active rheumatoid arthritis. A statistically significant elevation of the red cell manganese concentration was encountered in patients with rheumatoid arthritis. This argued against the presence of classical trace-

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Section: Discussionmentioning

confidence: 99%