A terpene cyclase from <i>Aspergillus ustus</i> is involved in the biosynthesis of geosmin precursor germacradienol

Peter, Marlies; Yang, Yiling; Li, Shu‐Ming

doi:10.1039/d2ra05033a

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Further functional characterization will be required to gain evidence for the function of ges1 . Recently, a terpene synthase for (1(10) E ,5 E )‐germacradien‐11‐ol ( 3 ) was discovered from Aspergillus ustus , suggesting that this compound may also be an intermediate in fungal geosmin biosynthesis, but the conversion of 3 into geosmin has not been shown (Peter et al, 2022). Taken together, the molecular basis for geosmin biosynthesis in fungi is currently unclear.…”

Section: Biosynthesis Of Geosminmentioning

confidence: 99%

Volatile sensation: The chemical ecology of the earthy odorant geosmin

Garbeva

Ávalos

Ulanová

et al. 2023

Environmental Microbiology

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Geosmin may be the most familiar volatile compound, as it lends the earthy smell to soil. The compound is a member of the largest family of natural products, the terpenoids. The broad distribution of geosmin among bacteria in both terrestrial and aquatic environments suggests that this compound has an important ecological function, for example, as a signal (attractant or repellent) or as a protective specialized metabolite against biotic and abiotic stresses. While geosmin is part of our everyday life, scientists still do not understand the exact biological function of this omnipresent natural product. This minireview summarizes the current general observations regarding geosmin in prokaryotes and introduces new insights into its biosynthesis and regulation, as well as its biological roles in terrestrial and aquatic environments.

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Section: Biosynthesis Of Geosminmentioning

confidence: 99%

Volatile sensation: The chemical ecology of the earthy odorant geosmin

Garbeva

Ávalos

Ulanová

et al. 2023

Environmental Microbiology

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A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors

Martin,

Dierlamm,

Zocher

et al. 2023

Appl Microbiol Biotechnol

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The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the presence of both dimethylallyl and geranyl diphosphate. Although the natural substrate of ShPT remains unknown, our results provide one additional prenyltransferase from basidiomycetes, which are less studied, in comparison to those from other sources. Furthermore, this study expands the chemical toolbox for regioselective production of prenylated naphthalene derivatives. Key points •Basidiomycetous prenyltransferase •Biochemical characterization •A DMATS prenyltransferase prenylating hydroxynaphthalene derivatives

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A terpene cyclase from Aspergillus ustus is involved in the biosynthesis of geosmin precursor germacradienol

Abstract: This study reports a terpene cyclase responsible for germacradienol formation in the ascomycetous fungus Aspergillus ustus. Both in vivo and in vitro data are provided.

Cited by 2 publications

References 24 publications

Volatile sensation: The chemical ecology of the earthy odorant geosmin

Volatile sensation: The chemical ecology of the earthy odorant geosmin

A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors

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