A terahertz metamaterial biosensor for sensitive detection of microRNAs based on gold-nanoparticles and strand displacement amplification

Flexible Terahertz Metamaterial Biosensor for Ultra-Sensitive Detection of Hepatitis B Viral DNA Based on the Metal-Enhanced Sandwich Assay

“…The localized electric field present in the gaps of the MM chip enhanced the interactions between the DNA and THz wave, which was further enhanced by the gold nanoparticles (AuNPs) due to their high refractive index, thus verifying that AuNPs can increase the THz biosensing signal (Yang et al, 2021;Zhan et al, 2021). Here, the GMNPs-RCA-AuNPs sandwich assay was refined to improve the sensitivity of DNA detection based on the THz MM biosensor.…”

Metal–organic frameworks towards bio-medical applications

“…A variety of materials such as metallic nanoparticles, 36,37 graphene Oxide (GO), 38 silica nanoparticles, 39 quantum dots 40 or metal-organic frameworks, 41,42 have been used as platforms for the design of biosensors. Among them, MOFs with specific functional sites have sparked a lot of interest because of their diverse structures and multifunctionalities, allowing for specific molecular recognition and fluorescence generation and/or change.…”

A dual-functional fluorescent biosensor based on enzyme-involved catalytic hairpin assembly for the detection of APE1 and miRNA-21

“…To meet the requirement for miRNA-21 detection, signal amplification strategies are usually introduced to enhance the sensitivity of fluorescent biosensors. Up to now, there are several signal amplification pathways, including nicking enzyme assisted signal amplification (NEASA), [16][17][18] rolling circle amplification (RCA), [19][20][21][22][23][24] strand displacement amplification (SDA), [25][26][27][28] hybridized chain reaction (HCR), [29][30][31][32] and CHA. [33][34][35][36][37] Among these signal amplification pathways, CHA has become universally acceptable for fluorescent biosensors, owing to its unique advantages of low background signals, high efficiency, simplicity of design, and ease of operation.…”