A Temperature-Differential Affinity Biosensor: Model and ${\rm D}$-Optimal Performance Limits

Horesh, Moran; Lidich, Nina; Yitzchaik, Shlomo; Hanein, Yael

doi:10.1109/jsen.2011.2106156

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…Consequently, the main limitation on the attainable FOM in our structure is signal to noise ratio and not the intrinsic quality factor of the plasmonic modes, thus allowing for even higher FOMs. Moreover, additional improvement of the sensitivity and FOM can be attained through employment of advanced sensitivity enhancement techniques such as temperature differential methods 44 or even through a configuration change such as directing the light through the substrate, rather than through the analyte. Finally, the concept can be easily converted to other desired wavelengths and RI ranges by modifying the slot dimensions and the array spacing, thus rendering it highly useful for numerous sensing applications including biosensing, water contaminant testing, and more.…”

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confidence: 99%

Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing

Eitan¹,

Iluz²,

Yifat³

et al. 2015

ACS Photonics

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We introduce an ultrasensitive detection technique for refractive index (RI) sensing based on an array of nanometer scale slot-antennas milled in a thin gold layer using a single lithographic step. Our experimental figures of merit (FOMs) of 140-210 in the telecom wavelength range approach the fundamental limit for standard propagating SPR sensors (~250).The underlying mechanism enabling this is the combination of a narrowband resonance of the slot-antennas with degeneracy breaking of Wood's anomaly under slightly non-perpendicular illumination. In addition, we explore the sensitivity of the device to the depth of the analyte layer. This concept can be easily tuned to any desired wavelength and RI range by modifying the slot dimensions and the array spacing, thus rendering it highly useful for numerous sensing applications.

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confidence: 99%

Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing

Eitan¹,

Iluz²,

Yifat³

et al. 2015

ACS Photonics

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“…• Employing multiple antennas with different types of receptors each corresponding to a different ligand as shown in Fig. 12( complex signal processing on the electrical signal to discriminate the contributions of different messages [52].…”

Section: A Molecular Division Multiple Access (Mdma) and Moskmentioning

confidence: 99%

On the Physical Design of Molecular Communication Receiver Based on Nanoscale Biosensors

Kuscu

Akan

2016

IEEE Sensors J.

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Molecular communications (MC), where molecules are used to encode, transmit, and receive information, is a promising means of enabling the coordination of nanoscale devices. The paradigm has been extensively studied from various aspects, including channel modeling and noise analysis. Comparatively little attention has been given to the physical design of molecular receiver and transmitter, envisioning biological synthetic cells with intrinsic molecular reception and transmission capabilities as the future nanomachines. However, this assumption leads to a discrepancy between the envisaged applications requiring complex communication interfaces and protocols, and the very limited computational capacities of the envisioned biological nanomachines. In this paper, we examine the feasibility of designing a molecular receiver, in a physical domain other than synthetic biology, meeting the basic requirements of nanonetwork applications. We first review the state-of-the-art biosensing approaches to determine whether they can inspire a receiver design. We reveal that nanoscale field effect transistor based electrical biosensor technology (bioFET) is a particularly useful starting point for designing a molecular receiver. Focusing on bioFET-based molecular receivers with a conceptual approach, we provide a guideline elaborating on their operation principles, performance metrics and design parameters. We then provide a simple model for signal flow in silicon nanowire (SiNW) FET-based molecular receiver. Lastly, we discuss the practical challenges of implementing the receiver and present the future research avenues from a communication theoretical perspective.

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A Temperature-Differential Affinity Biosensor: Model and ${\rm D}$-Optimal Performance Limits

Cited by 2 publications

References 31 publications

Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing

Degeneracy Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing

On the Physical Design of Molecular Communication Receiver Based on Nanoscale Biosensors

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