A teenager with ductal carcinoma in situ arising in a fibroadenoma: a case report

Abstract

Breast cancer arising within fibroadenomas (BcaFad) is a very rare finding. BcaFad occurs mostly in women between the ages of 40 and 50. This report details the unique case of an 18-year-old woman with bcafad. We present an 18-year-old woman with a ductal carcinoma in situ (DCIS) arising within a fibroadenoma. This is the youngest reported case of BcaFad in the literature. Clinically, the mass presented characteristics of a benign breast lump. Microscopically, an atypical proliferation of luminal epithelial cells was classified as a low-grade DCIS. As a very rare presentation at an especially unusual age, this case challenges the current risk evaluation and management in young women diagnosed with fibroadenoma.

Breast Carcinoma Arising in Fibroadenoma in a 15-Year-Old Girl; Diagnosis and Treatment Challenge

“…The average age of patients with Bcafad is in the fifties. A case of Bcafad in an 18-year-old girl was recently reported [3]. To our knowledge, we report the first case occurring in a 15-year-old girl in the literature.…”

“…Management depends on the stage of the disease, but also changes in body image, sexual functioning and the risk of infertility must be taken into account [12] [13]. Oliver Frisch reported a case of Bcafad in an 18-year-old girl with carcinoma in situ whose treatment was surgery alone [3]. Our patient received neoadjuvant chemotherapy with 5-Fluorouracil, Adribalstine and Cyclophosphamide followed by mastectomy and lymph node dissection.…”

Ductal carcinoma in situ arising from fibroadenoma; a rare case with review of literature

“…It is uncertain whether FA increases the likelihood of breast cancer development [ 9 ]. Dupont et al reported that the risk of developing invasive breast cancer (IBC) is about 2.17 times greater among patients with FA in comparison to non-fibroadenoma patients [ 10 ].…”

“…Approximately two-thirds of carcinomas within FAs are lobular, and the remaining one-third are ductal or mixed [ 12 ]. Malignant changes within FAs typically occur at an older age, with the age of detection in the fifth decade [ 9 , 13 ]. Complex FAs have a higher tendency for malignant transformation than non-complex FAs [ 14 ].…”

Carcinoma Ductal in situ mamário associado a fibroadenoma em paciente de 18 anos

“…A faixa etária mais acometida é dos 40 aos 45 anos, isto é, 15 a 20 anos após a média de idade de ocorrência do fibroadenoma. 1 Foi encontrado apenas um relato, de uma jovem adolescente com fibroadenoma associado a um carcinoma ductal in situ 6 .…”