A technology for the investigation of biofilm transmission under shearing pressures

Matilla, Miguel A.

doi:10.1111/1751-7915.12848

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…This well developed biofilm resembles a communal group arbitrated by chemical signaling molecules liberated by bacterial inhabitants within the biofilm. On maturation, the microcolonies of cells release individual planktonic cells now capable of travelling to a new surface, thus leading to outspread of the bacterial infestation [98][99][100][101].…”

Section: Maturation Of the Biofilm And Detachmentmentioning

confidence: 99%

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

et al. 2022

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A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix produced by themselves. Many types of microorganisms that are found on living hosts or in the environment can form biofilms. These include pathogenic bacteria that can serve as a reservoir for persistent infections, and are culpable for leading to a broad spectrum of chronic illnesses and emergence of antibiotic resistance making them difficult to be treated. The absence of biofilm-targeting antibiotics in the drug discovery pipeline indicates an unmet opportunity for designing new biofilm inhibitors as antimicrobial agents using various strategies and targeting distinct stages of biofilm formation. The strategies available to control biofilm formation include targeting the enzymes and proteins specific to the microorganism and those involved in the adhesion pathways leading to formation of resistant biofilms. This review primarily focuses on the recent strategies and advances responsible for identifying a myriad of antibiofilm agents and their mechanism of biofilm inhibition, including extracellular polymeric substance synthesis inhibitors, adhesion inhibitors, quorum sensing inhibitors, efflux pump inhibitors, and cyclic diguanylate inhibitors. Furthermore, we present the structure–activity relationships (SAR) of these agents, including recently discovered biofilm inhibitors, nature-derived bioactive scaffolds, synthetic small molecules, antimicrobial peptides, bioactive compounds isolated from fungi, non-proteinogenic amino acids and antibiotics. We hope to fuel interest and focus research efforts on the development of agents targeting the uniquely complex, physical and chemical heterogeneous biofilms through a multipronged approach and combinatorial therapeutics for a more effective control and management of biofilms across diseases.

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Section: Maturation Of the Biofilm And Detachmentmentioning

confidence: 99%

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

et al. 2022

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“…It is a process by which bacterial cells or communities interact and regulate their complex physiological processes due to signaling molecules termed "auto-inducers" and their receptors. Specific properties like virulence and antibiotic resistance result from genes expressed after the interaction of auto-inducers with their receptor [11]. Gram-negative bacteria produce acylated homoserine lactones (AHLs) as auto-inducers.…”

Section: Significance Of Quorum Sensing In Biofilm Dispersionmentioning

confidence: 99%

“…Cyclic dimeric guanosine monophosphate (c-di-GMP) is a secondary messenger first reported in Acetobacter xylinum as an activator of cellulose production [11]. Elevated levels of c-di-GMP promote sessile biofilm structure.…”

Section: C-di-gmp's Role In Biofilm Dispersionmentioning

confidence: 99%

Biofilm Detachment and Its Implication in Spreading Biofilm-Related Infections

Gupta¹,

Srivastava²,

Agarwal³

2022

Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022)

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Biofilms are a community of microorganisms formed on both abiotic and biotic surfaces. These colonies play a vital role in the virulent life cycle of bacteria. Bacteria communicate intrinsically and extrinsically to grow and eventually disperse their virulent factors, ultimately leading to diseases. Biofilm dispersion is the last stage in this life cycle; at this stage, the biofilm has completed maturation. The microorganism then disperses as the biofilm ruptures and assumes a planktonic lifestyle until they find a new surface to attach to and repeat the cycle. This mechanism plays a vital role in the pathogenicity of the microorganism and can be triggered prematurely to disrupt the microorganism's virulent nature. In this mini-review, we have summarized biofilm dispersion, its mechanisms, and the factors influenced by, focusing on their effect on the pathogen's virulence. We have also discussed the significance of quorum sensing and the modern methods used to develop quorum sensing inhibitors through in-silico approaches.

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“…Differential expression of genes also contributes to active dispersal; cell motility and polysaccharide degradation associated genes such as flagella biosynthesis and dispersin secretion are upregulated, while EPS production genes are downregulated (McDougald et al, 2011;Toyofuku et al, 2016). In contrast, passive dispersal is a process of biofilm detachment that involves physical forces like hydrodynamic shear, abrasion, or mechanical intervention (Kaplan, 2010;Matilla, 2017).…”

Section: Introduction To Bacterial Biofilmsmentioning

confidence: 99%

The role of bacteriophages in mixed microbial communities and populations of Pseudomonas aeruginosa

Ismail¹

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A technology for the investigation of biofilm transmission under shearing pressures

Cited by 4 publications

References 25 publications

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

Biofilm Detachment and Its Implication in Spreading Biofilm-Related Infections

The role of bacteriophages in mixed microbial communities and populations of Pseudomonas aeruginosa

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