A Technical Review on Existing pH Detection and Monitoring Technology for in-Vivo Diagnostic Application

Gonzales, Ruth Maica C.; Pacis, Danica Mitch M.; Bugtai, Nilo T.; Cu, Janella Marie M.

doi:10.1109/hnicem51456.2020.9400104

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…The development of flexible and wearable chemical (bio) sensing systems with wireless data readout and transmission use, though have poor reliability. [18][19][20] Further, they only allow single-in-time measures and are not suitable for continuous pH tracking. On the other hand, accurate and continuous measurements of vaginal pH in situ from a few hours to days are of key importance for prevention, early diagnosis, and treatment of BV.…”

Section: Introductionmentioning

confidence: 99%

Wireless and Flexible Optoelectronic System for In Situ Monitoring of Vaginal pH Using a Bioresorbable Fluorescence Sensor

Paghi

Corsi

Mattina

et al. 2023

Adv Materials Technologies

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Herein, a miniaturized wireless sensing vaginal ring for the in situ continuous monitoring of vaginal pH and real‐time transmission of the pH data to a smartphone is reported, aimed at the diagnosis and management of bacterial vaginosis, a common condition frequently and adversely affecting women. The sensing vaginal ring consists of a bioresorbable pH fluorescence sensor placed on top of a polydimethylsiloxane ring encapsulating a miniaturized driving/readout optoelectronic circuit, data acquisition system, wireless transceiver, and power supply. The pH sensor consists of a micrometer‐thick porous silica scaffold conformably coated with a nanometer‐thick polymer multilayer stack and is intended to be replaced after 4 days. The sensor fully dissolves in biocompatible by‐products eliminating waste management issues; conversely, the ring embedding the circuit is reusable with new sensors. The pH sensor, as well as the sensing vaginal ring, show excellent performance in the continuous measurement of pH in vaginal fluid and can monitor the pH level over the physio‐pathological range of 3–7.5 with high linearity, accuracy, and reliability, transmitting the data to a smartphone in real time. The proposed technology can be immediately translated to other diseases, among which wound healing, intragastric activity, and cancer progression, where continuous monitoring of pH is required, as well as to other markers/analytes by engineering the polymer stack with suitable receptors, such as aptamers and other molecular probes.

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Section: Introductionmentioning

confidence: 99%

Wireless and Flexible Optoelectronic System for In Situ Monitoring of Vaginal pH Using a Bioresorbable Fluorescence Sensor

Paghi

Corsi

Mattina

et al. 2023

Adv Materials Technologies

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“…electrochemical [14]- [19] methods have been proposed in the literature for industrial, agri-food, and biomedical applications [20], [21]. Besides, commercial devices are available for blood-pH measuring during ECC [22].…”

Section: Introductionmentioning

confidence: 99%

Blood-pH Optical Measurement: A Model to Compensate for the Effects of Temperature

Goldoni

Ferrari

Piccini

et al. 2023

IEEE Trans. Instrum. Meas.

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Under physiological conditions, the human body maintains blood pH within [7.36, 7.44] pH. Small deviations from this range can reveal the onset of pathological states and worsen the patient's condition. This paper reports the performance analysis of a real-time, non-invasive pH measuring system for extracorporeal circulation (ECC). In particular, this study focuses on the analysis of the effects that the measurand temperature may have on the error in estimating blood pH. Even if the blood temperature in ECC is often thermostated at 37 °C, there are treatments in which the blood temperature is varied by a few Celsius degrees, and the exploited measurement principle -fluorescence -is known to be affected by temperature.First, we verified that the temperature-induced error could exceed the maximum permissible measurement error of ±0.04 pH. Hence a linear correction factor for temperature compensation was proposed. The results obtained showed how the simple addition to the measuring system of a temperature sensor and the use of a linear correction factor can effectively allow maintaining the measurement error within the ±0.04 pH range, even when the fluid -phosphate buffer saline (PBS) and blood -temperature is varied in the range [30, 39] °C.

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Ion Sensitive Field Effect Transistor as a Bio-compatible Device: A Review

Majji

Dash

Panigrahy³

2022

2022 International Conference on Electronics and Renewable Systems (ICEARS)

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A Technical Review on Existing pH Detection and Monitoring Technology for in-Vivo Diagnostic Application

Cited by 3 publications

References 30 publications

Wireless and Flexible Optoelectronic System for In Situ Monitoring of Vaginal pH Using a Bioresorbable Fluorescence Sensor

Wireless and Flexible Optoelectronic System for In Situ Monitoring of Vaginal pH Using a Bioresorbable Fluorescence Sensor

Blood-pH Optical Measurement: A Model to Compensate for the Effects of Temperature

Ion Sensitive Field Effect Transistor as a Bio-compatible Device: A Review

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