A Technical Report on the Performance of Percutaneous Cryoneurolysis of Splanchnic Nerves for the Treatment of Refractory Abdominal Pain in Patients with Pancreatic Cancer: Initial Experience

Filippiadis, Dimitrios; Ptohis, Nikolaos; Efthymiou, Evgenia; Kelekis, Alexis

doi:10.1007/s00270-020-02756-3

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…42 All five patients reported statistically significant reductions in VAS at 1, 3, and 6 months following the procedure, in addition to reduction in analgesic usage. 42 Multiple additional studies targeting the splanchnic nerves, rather than the celiac plexus, further support splanchnic nerve cryoneurolysis for treatment of refractory abdominal pain in the setting of intra-abdominal cancer. 43,44 Moving forward, it is likely that cryoneurolysis will continue to be applied to a number of cancer-related pain syndromes.…”

Section: Cryoneurolysismentioning

confidence: 82%

“…reported their experience with splanchnic nerve cryoneurolysis in five adult patients with pancreatic cancer and refractory abdominal pain 42 . All five patients reported statistically significant reductions in VAS at 1, 3, and 6 months following the procedure, in addition to reduction in analgesic usage 42 . Multiple additional studies targeting the splanchnic nerves, rather than the celiac plexus, further support splanchnic nerve cryoneurolysis for treatment of refractory abdominal pain in the setting of intra‐abdominal cancer 43,44 …”

Section: Cryoneurolysismentioning

confidence: 97%

“…Recently, Filippiadis et al. reported their experience with splanchnic nerve cryoneurolysis in five adult patients with pancreatic cancer and refractory abdominal pain 42 . All five patients reported statistically significant reductions in VAS at 1, 3, and 6 months following the procedure, in addition to reduction in analgesic usage 42 .…”

Section: Cryoneurolysismentioning

confidence: 99%

See 2 more Smart Citations

Introduction to interventional radiology's role in palliative care for children with cancer: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

Hawkins

Gill

2023

Pediatric Blood & Cancer

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As palliative care continues to be an area of increasing emphasis in pediatric oncology programs, it is important to raise awareness about minimally invasive, image‐guided procedures that can supplement more conventional palliative interventions, such as systemic analgesics, external beam radiation, and locoregional anesthesia. These procedures, when performed for appropriately selected patients, can often facilitate discharge from an inpatient facility, and help patients meet their end‐of‐life goals. This article specifically discusses three palliative procedures performed by interventional radiologists that can assist pediatric palliative care teams in: (a) percutaneous thermal ablation of painful bone metastases, (b) cryoneurolysis, and (c) tunneled drainage catheter placement for malignant pleural effusions and ascites.

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Section: Cryoneurolysismentioning

confidence: 82%

Section: Cryoneurolysismentioning

confidence: 97%

Section: Cryoneurolysismentioning

confidence: 99%

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Introduction to interventional radiology's role in palliative care for children with cancer: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

Hawkins

Gill

2023

Pediatric Blood & Cancer

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“…According to Aitken et al (12), pain treatment accounts for 16.6% of PCs. Currently, visual simulation scoring methods (13) and digital scoring methods are mainly used to evaluate PC pain. However, these scoring methods are all subjective evaluations and impact feedback on the degree of pain.…”

Section: Discussionmentioning

confidence: 99%

- Mechanism of LDH and IL-8 Involved in pancreatic cancer Pain and the Correlation of Pain Degree

2024

J Med Biochem

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Objective: To observe the mechanism of lactate dehydrogenase (LDH) and interleukin 8 (IL-8) in pancreatic cancer pain and their correlation with pain degree. Methods: 126 patients with pancreatic cancer who visited our hospital from January 2021 to February 2023 were selected. The patients were divided into 58 patients with low pain (1~3 points) and 68 patients with high pain (4~10 points) by visual analog scale (VAS). And 50 health examinees in the same period were selected as the healthy control group. The serum LDH and IL-8 concentrations are analyzed by enzyme-linked immunosorbent assay, as well as the subjective pain grading method scoreis analyzed. The differences in LDH and IL-8 concentrations among the three groups of patients were compared. Pearson correlation analysis was used to investigate the correlation between LDH, IL-8 concentrations and patient pain. Binary logistic regression was used to determine independent risk factors for high pain, and ROC curves were used to analyze the diagnostic efficacy of each indicator. Result: The serum LDH and IL-8 concentrations in the high pain group were exceed the low pain group’s (P<0.05). The serum LDH and IL-8 concentrations in the low pain groupexceed the healthy control group’s(P<0.05). Pearson correlation analysis revealed a positive correlation between serum LDH concentration and pain grading (r=0.736, P=0.000). The serum IL-8 has positive correlation with pain grading (r=0.680, P=0.000). Serum LDH and IL-8 concentrations have positive correlation(r=0.589, P=0.000). LDH and IL-8 concentrations are independent risk factors for high pain levels (OR=1.033, 1.142, P<0.05). The logistic regression prediction model formula was used: Y=constant+B1X1+B2X2+...+BnXn to set the joint diagnostic prediction model as -12.063+0.033×LDH+0.133×IL-8. The areas under the ROC curves of LDH, IL-8, and predictive model (LDH+IL-8) in patients with high pain were 0.925, 0.945, and 0.974, respectively. The relevant standards for LDH are>190U/L, IL-8 is>36pg/mL, and the relevant standards for prediction models are>5.75. Conclusion: LDH and IL-8 participate in the pain aggravation process of pancreatic cancer, and are closely related to the pain grading. The combination of LDH and IL-8 can be used as a biological indicator to evaluate the pain severity of pancreatic cancer, and provide reference for clinical diagnosis and treatment.

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Percutaneous Cryoneurolysis of Splanchnic Nerves Under Combined Computed Tomography and Endoscopy Guidance: Pushing the Boundaries of Hybrid Imaging

Torres,

Giannakis,

Kelekis

et al. 2024

Cardiovasc Intervent Radiol

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A Technical Report on the Performance of Percutaneous Cryoneurolysis of Splanchnic Nerves for the Treatment of Refractory Abdominal Pain in Patients with Pancreatic Cancer: Initial Experience

Cited by 9 publications

References 19 publications

Introduction to interventional radiology's role in palliative care for children with cancer: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

Introduction to interventional radiology's role in palliative care for children with cancer: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

- Mechanism of LDH and IL-8 Involved in pancreatic cancer Pain and the Correlation of Pain Degree

Percutaneous Cryoneurolysis of Splanchnic Nerves Under Combined Computed Tomography and Endoscopy Guidance: Pushing the Boundaries of Hybrid Imaging

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