a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect

Làdavas, Elisabetta; Giulietti, Sara; Avenanti, Alessio; Bertini, Caterina; Lorenzini, Eleonora; Quinquinio, Cristina; Serino, Andrea

doi:10.3233/rnn-140464

Cited by 45 publications

(68 citation statements)

References 93 publications

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“…An implication of prefrontal circuits in neglect compensation has been hypothesized on the basis of behavioral evidence 40 , and recently confirmed by electrophysiological measures 41 . Also consistent with our results, cathodal transcranial direct current stimulation applied over the left posterior parietal cortex interfered with the beneficial effect of PA on neglect 42 .…”

Section: Discussionsupporting

confidence: 92%

“…An implication of prefrontal circuits in neglect compensation has been hypothesized on the basis of behavioural evidence (Bartolomeo, 1997;Bartolomeo, 2000), and recently confirmed by electrophysiological measures (Takamura et al, 2016). Also consistent with our results, 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 14 cathodal transcranial direct current stimulation applied over the left posterior parietal cortex interfered with the beneficial effect of PA on neglect (Làdavas et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Anatomical predictors of successful prism adaptation in chronic visual neglect

Lunven

Rode

Bourlon

et al. 2017

Preprint

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Visual neglect is a frequent and disabling consequence of right hemisphere damage. Previous evidence demonstrated a probable role of posterior callosal dysfunction in the chronic persistence of neglect signs. Prism adaptation is a non-invasive and convenient technique to rehabilitate chronic visual neglect, but it is not effective in all patients. Here we hypothesized that prism adaptation improves left neglect by facilitating compensation through the contribution of the left, undamaged hemisphere. To test this hypothesis, we assessed the relationship between prism adaptation effects, cortical thickness and white matter integrity in a group of 14 patients with unilateral right-hemisphere strokes and chronic visual neglect. Consistent with our hypothesis, patients who benefitted from prism adaptation had a thicker cortex in temporo-parietal, prefrontal and cingulate areas of the left, undamaged hemisphere.Additionally, these patients had higher microstructural integrity of the body and genu of the corpus callosum. These callosal regions connect temporo-parietal, sensorimotor and prefrontal areas. Thus, prism adaptation may ameliorate signs of left visual neglect by promoting the contribution of the left hemisphere to neglect compensation. These results support current hypotheses on the role of the healthy hemisphere in the compensation for stroke-induced, chronic neuropsychological deficits, and suggest that prism adaptation can foster this role by exploiting sensorimotor/prefrontal circuits for neglect compensation. Highlights:• Visual neglect is a disabling condition resulting from right hemisphere damage • Prism adaptation is a promising therapy, but not all patients respond • We assessed the anatomical predictors of patients' response to prism adaptation • Study of cortical thickness and white matter integrity • Importance of fronto-parietal networks in the left, healthy hemisphere for recovery • Importance of callosal connections in the genu and body for recovery

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Anatomical predictors of successful prism adaptation in chronic visual neglect

Lunven

Rode

Bourlon

et al. 2017

Preprint

View full text Add to dashboard Cite

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“…Fourteen events led to discontinuation of the treatment (Gillick et al, 2015; Jo et al, 2009; Kim et al, 2010; Làdavas et al, 2015; Mortensen et al, 2016; Polanowska et al, 2013; Rosso et al, 2014; Shigematsu et al, 2013; Smit et al, 2015; Sparing et al, 2009; Straudi et al, 2016; Sunwoo et al, 2013; Triccas et al, 2015; Wang et al, 2014; You et al, 2011). …”

Section: The Application Of Low Intensity Tes In Human Studies: Aementioning

confidence: 99%

Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines

Antal

Alekseichuk

Bikson

et al. 2017

Clinical Neurophysiology

877

728

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Low intensity transcranial electrical stimulation (TES) in humans, encompassing transcranial direct current (tDCS), transcutaneous spinal Direct Current Stimulation (tsDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation or their combinations, appears to be safe. No serious adverse events (SAEs) have been reported so far in over 18,000 sessions administered to healthy subjects, neurological and psychiatric patients, as summarized here. Moderate adverse events (AEs), as defined by the necessity to intervene, are rare, and include skin burns with tDCS due to suboptimal electrode-skin contact. Very rarely mania or hypomania was induced in patients with depression (11 documented cases), yet a causal relationship is difficult to prove because of the low incidence rate and limited numbers of subjects in controlled trials. Mild AEs (MAEs) include headache and fatigue following stimulation as well as prickling and burning sensations occurring during tDCS at peak-to-baseline intensities of 1–2 mA and during tACS at higher peak-to-peak intensities above 2 mA. The prevalence of published AEs is different in studies specifically assessing AEs vs. those not assessing them, being higher in the former. AEs are frequently reported by individuals receiving placebo stimulation. The profile of AEs in terms of frequency, magnitude and type is comparable in healthy and clinical populations, and this is also the case for more vulnerable populations, such as children, elderly persons, or pregnant women. Combined interventions (e.g., co-application of drugs, electrophysiological measurements, neuroimaging) were not associated with further safety issues. Safety is established for low-intensity ‘conventional’ TES defined as <4 mA, up to 60 min duration per day. Animal studies and modeling evidence indicate that brain injury could occur at predicted current densities in the brain of 6.3–13 A/m2 that are over an order of magnitude above those produced by tDCS in humans. Using AC stimulation fewer AEs were reported compared to DC. In specific paradigms with amplitudes of up to 10 mA, frequencies in the kHz range appear to be safe. In this paper we provide structured interviews and recommend their use in future controlled studies, in particular when trying to extend the parameters applied. We also discuss recent regulatory issues, reporting practices and ethical issues. These recommendations achieved consensus in a meeting, which took place in Göttingen, Germany, on September 6–7, 2016 and were refined thereafter by email correspondence.

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“…Possibly this is due to their low sample size (n = 5)-a problem that plagues all these studies-or because their patients were in the later, chronic stage of stroke, when recovery is more difficult. Still, the null result by Smit et al (2015) carries some weight, as their study was relatively well-designed: it included multiple patients, was sham-controlled, and had multiple (five) stimulation sessions-only two other studies fit all these criteria (Làdavas et al 2015;Yi et al 2016).…”

Section: Hemispatial Neglectmentioning

confidence: 99%

Transcranial Electrical Stimulation as a Tool to Enhance Attention

et al. 2017

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Attention is a fundamental cognitive process-without it, we would be helplessly adrift in an overload of sensory input. There is considerable interest in techniques that can be used to enhance attention, including transcranial electrical stimulation (tES). We present an overview of 52 studies that have paired attention tasks with tES, mostly in the form of transcranial direct current stimulation (tDCS). In particular, we discuss four aspects of attention that have been most extensively targeted to date: visual search, spatial orienting (e.g., Posner cueing tasks), spatial bias (e.g., line bisection tasks), and sustained attention. Some promising results have been reported in each of these domains. However, drawing general conclusions about the efficacy of tES is at present hampered by a large diversity in study design and inconsistent findings. We highlight some pitfalls and opportunities and suggest how these may be addressed in future research aiming to use tES as a tool to enhance or test theoretical hypotheses about attention.

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a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect

Cited by 45 publications

References 93 publications

Anatomical predictors of successful prism adaptation in chronic visual neglect

Anatomical predictors of successful prism adaptation in chronic visual neglect

Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines

Transcranial Electrical Stimulation as a Tool to Enhance Attention

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