A taxonomy for responsiveness

Beaton, Dorcas; Bombardier, Claire; Katz, Jeffrey N.; Wright, James G.

doi:10.1016/s0895-4356(01)00407-3

Cited by 430 publications

(354 citation statements)

References 101 publications

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“…As with many HRQOL measures, the interpretation of the data may be problematic and should not be based solely on P values, especially if HRQOL is a secondary outcome when a trial tends not to be powered for HRQOL. To aid the interpretation of the LupusQoL, evaluation is required to assess its sensitivity to change (the ability to detect an improvement or deterioration when patients deem themselves to have improved or deteriorated) 10 as advocated by the regulatory bodies 2, and to estimate the minimal important difference (MID), the smallest difference that patients perceive as beneficial or harmful 11.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

McElhone

Abbott

Sutton

et al. 2016

Arthritis Care & Research

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ObjectiveAs a health‐related quality of life (HRQOL) measure, the LupusQoL is a reliable and valid measure for adults with systemic lupus erythematosus (SLE). This study evaluates the responsiveness and minimal important differences (MIDs) for the 8 LupusQoL domains.MethodsPatients experiencing a flare were recruited from 9 UK centers. At each of the 10 monthly visits, HRQOL (LupusQoL, Short Form 36 health survey [SF‐36]), global rating of change (GRC), and disease activity using the British Isles Lupus Assessment Group 2004 index were assessed. The responsiveness of the LupusQoL and the SF‐36 was evaluated primarily when patients reported an improvement or deterioration on the GRC scale and additionally with changes in physician‐reported disease activity. MIDs were estimated as mean changes when minimal change was reported on the GRC scale.ResultsA total of 101 patients were recruited. For all LupusQoL domains, mean HRQOL worsened when patients reported deterioration and improved when patients reported an improvement in GRC; SF‐36 domains showed comparable responsiveness. Improvement in some domains of the LupusQoL/SF‐36 was observed with a decrease in disease activity, but when disease activity worsened, there was no significant change. LupusQoL MID estimates for deterioration ranged from −2.4 to −8.7, and for improvement from 3.5 to 7.3; for the SF‐36, the same MID estimates were −2.0 to −11.1 and 2.8 to 10.9, respectively.ConclusionAll LupusQoL domains are sensitive to change with patient‐reported deterioration or improvement in health status. For disease activity, some LupusQoL domains showed responsiveness when there was improvement but none for deterioration. LupusQoL items were derived from SLE patients and provide the advantage of disease‐specific domains, important to the patients, not captured by the SF‐36.

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Section: Introductionmentioning

confidence: 99%

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

McElhone

Abbott

Sutton

et al. 2016

Arthritis Care & Research

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“…In general, the psychometric property associated with the ability to measure change is called 'responsiveness' or 'sensitivity to change', although many variations on this definition exist. 17 In the present study, we use the term 'responsiveness' as this term is used more often in literature, although the term 'sensitivity to change' may be more comprehensible in clinical use.…”

Section: Introductionmentioning

confidence: 99%

Measuring change in arm hand skilled performance in persons with a cervical spinal cord injury: responsiveness of the Van Lieshout Test

Spooren¹,

Janssen-Potten²,

Post

et al. 2006

Spinal Cord

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Objectives: To asses whether the Van Lieshout Test (VLT) is responsive to measure changes in arm hand skilled performance (AHSP) over time during active rehabilitation in persons with cervical spinal cord injury (C-SCI) and in different subgroups of persons with C-SCI according to lesion completeness and to lesion level. Study design: Longitudinal cohort study. Setting: Spinal Cord Injury Units in eight rehabilitation centres across the Netherlands. Methods: In the present study, data from a national SCI cohort study are used. Data from the VLT, the Grasp Release Test (GRT), the Functional Independence Measure (FIM) and the Quadriplegia Index of Function (QIF) were recorded at three moments during active rehabilitation: at the start of active rehabilitation (t1), 3 months after t1 (t2) and at discharge (t3). Data have been analysed using three responsiveness measures, that is, the standardized response mean, the effect size and comparison of test scores measured at different times. Results: The VLT is responsive for the intervals t1-3, t1-2 and t2-3. The VLT can be used to measure changes in AHSP in persons with a C-SCI with an American Spinal Injury Association Impairment Scale (AIS) A or B score or an AIS C or D score, as well as in persons with a C3-C6 lesion or a C7-T1 lesion. The responsiveness of the VLT is significantly correlated to the GRT, but not to the FIM and the QIF. Conclusion: The VLT is responsive in measuring changes in AHSP during rehabilitation in persons with C-SCI.

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“…The magnitude of change in domain scores reported by patients was categorized into 3 groups (improved, worsened, and unchanged) by different MCIDs (Strand and Crawford, Devilliers et al, and McElhone et al and for the SF-36 and Devilliers et al and McElhone et al for the LupusQoL) and was measured using standardized response means (SRMs), a ratio of the observed change (baseline minus followup) to the SD of that change (19). Higher SRM values reflect greater degrees of responsiveness (SRM 0.30-0.50 = low, 0.5-0.8 = moderate, and >0.8 = high) (19).…”

mentioning

confidence: 99%

“…Higher SRM values reflect greater degrees of responsiveness (SRM 0.30-0.50 = low, 0.5-0.8 = moderate, and >0.8 = high) (19).…”

mentioning

confidence: 99%

Comparison of the Sensitivity to Change of the 36‐Item Short Form Health Survey and the Lupus Quality of Life Measure Using Various Definitions of Minimum Clinically Important Differences in Patients With Active Systemic Lupus Erythematosus

Nantes

Strand

et al. 2017

Arthritis Care & Research

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Objective. The Medical Outcomes Study Short Form 36 (SF-36) and Lupus Quality of Life (LupusQoL) are healthrelated quality of life questionnaires used in systemic lupus erythematosus (SLE). We first determined the hypothesistesting construct validity of the SF-36 and LupusQoL against disease activity in patients with active SLE and then compared the sensitivity to change of SF-36 and LupusQoL domains according to different definitions of minimum clinically important differences (MCIDs) for improvement and worsening in the current cohort. Methods. Seventy-eight clinically active SLE patients concurrently completed both questionnaires at their baseline and followup visits. Questionnaire domain scores were correlated with the SLE Disease Activity Index 2000 (SLEDAI-2K) and evaluated for floor/ceiling effects. The sensitivity to change of domains in each questionnaire was analyzed first, according to the various MCID definitions and, second, by clinically meaningful changes in disease activity. The magnitudes of change in each domain score between the baseline and followup visit were evaluated using standardized response means. Results. In the 78 patients, the mean AE SD SLEDAI-2K scores were 9.7 AE 4.8 at baseline and 8.8 AE 5.1 at followup. SF-36/LupusQoL domain scores did not correlate with disease activity. The SF-36 showed floor effects, and ceiling effects were evident in both questionnaires. All domains of both questionnaires showed sensitivity to change over time. Specific domains that reflected worsening or improvement differed according to differing MCID definitions. Conclusion. In SLE patients with active disease, both the SF-36 and LupusQoL are sensitive to change, reflecting both improvement and worsening. More importantly, the LupusQoL SLE-specific domains (planning, burden to others, body image, and intimate relationships) were largely responsive to change.

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A taxonomy for responsiveness

Cited by 430 publications

References 101 publications

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

Sensitivity to Change and Minimal Important Differences of the LupusQoL in Patients With Systemic Lupus Erythematosus

Measuring change in arm hand skilled performance in persons with a cervical spinal cord injury: responsiveness of the Van Lieshout Test

Comparison of the Sensitivity to Change of the 36‐Item Short Form Health Survey and the Lupus Quality of Life Measure Using Various Definitions of Minimum Clinically Important Differences in Patients With Active Systemic Lupus Erythematosus

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