A targeted phototheranostic agent with strong AIE effect and boosted type I ROS generation

Wang, Haoping; Zhang, Chuangxin; Liu, Ying; Li, Ruipeng; Li, Jianfang; Feng, Liheng

doi:10.1016/j.dyepig.2023.111517

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…In 2023, Wang et al augmented the DÀ A intensities by replacing the acceptor 1,2,3-benzotriazole (to form MTTzPy) with the strong donor 3,4-ethenedioxythiophene (to form MTOTPy) to reduce intramolecular ~EST and promote the generation of type I ROS (Figure 2C). [27] Additionally, Liu et al introduced a strong donor carbazole unit and utilized thiophene as a π-bridge to achieve a strong ICT effect to construct type I PSs (TCM-CPS) with NIR emission (Figure 2D). [28] Benefiting from the positive charges, TCM-CPS can bind and kill both Gram-positive and Gram-negative bacteria to facilitate wound recovery in mice, in addition to entering cancer cells for imaging-guided PDT.…”

Section: Imaging-guided Anticancer and Antibacterial Treatmentmentioning

confidence: 99%

Anion‐π⁺ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Liu,

Gong,

Jiang

et al. 2024

Chemistry A European J

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Fluorescence imaging‐guided photodynamic therapy (PDT) has attracted extensive attention due to its potential of real‐time monitoring the lesion locations and visualizing the treatment process with high sensitivity and resolution. Aggregation‐induced emission luminogens (AIEgens) show enhanced fluorescence and reactive oxygen species (ROS) generation after cellular uptake, giving them significant advantages in bioimaging and PDT applications. However, most AIEgens are unfavorable for the application in organisms due to their severe hydrophobicity. Anion‐π+ type AIEgens carry intrinsic charges that can effectively alleviate their hydrophobicity and improve their binding capability to cells, which is expected to enhance the bioimaging quality and PDT performance. This concept summarizes the applications of anion‐π+ type AIEgens in fluorescence imaging, fluorescence imaging‐guided photodynamic anticancer and antimicrobial therapy in recent years, hoping to provide some new ideas for the construction of robust photosensitizers. Finally, the current problems and future challenges of anion‐π+ AIEgens are discussed.

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Section: Imaging-guided Anticancer and Antibacterial Treatmentmentioning

confidence: 99%

Anion‐π⁺ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Liu,

Gong,

Jiang

et al. 2024

Chemistry A European J

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“…In addition, the ROS efficiency was enhanced when the ICT effect was improved. Wang et al also discovered effective molecular engineering to improve the efficiency of type I ROS after regulating the core building block [58]. In this work, the synthesized PS of MTPy had low‐efficiency type I ROS (·OH, O 2 ˙ − , and H 2 O 2 ) production, when the acceptor of alkyl‐substituted 1, 2, 3‐benzotriazole or donor of 3, 4‐ethylenedioxy‐thiophene was introduced into the MTPy to obtain MTTzPy and MTOPy; the newly prepared PSs showed enhanced production efficiency of ·OH, O 2 ˙ − , and H 2 O 2 .…”

Section: Building Blocks Of Aie‐active Type I Pssmentioning

confidence: 99%

Recent advances in aggregation‐induced emission–active type I photosensitizers with near‐infrared fluorescence: From materials design to therapeutic platform fabrication

Xie,

Li,

Zhao

et al. 2023

Luminescence

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Near‐infrared (NIR) fluorescence imaging–guided photodynamic therapy (PDT) technology plays an important role in treating various diseases and still attracts increasing research interests for developing novel photosensitizers (PSs) with outstanding performances. Conventional PSs such as porphyrin and rhodamine derivatives have easy self‐aggregation properties in the physiological environment due to their inherent hydrophobic nature caused by their rigid molecular structure that induces strong intermolecular stacking π–π interaction, leading to serious fluorescence quenching and cytotoxic reactive oxygen species (ROS) reduction. Meanwhile, hypoxia is an inherent barrier in the microenvironment of solid tumors, seriously restricting the therapeutic outcome of conventional PDT. Aforementioned disadvantages should be overcome urgently to enhance the therapeutic effect of PSs. Novel NIR fluorescence–guided type I PSs with aggregation‐induced emission (AIE), which features the advantages of improving fluorescent intensity and ROS generation efficiency at aggregation as well as outstanding oxygen tolerance, bring hope for resolving aforementioned problems simultaneously. At present, plenty of research works fully demonstrates the advancement of AIE‐active PDT based on type I PSs. In this review, cutting‐edge advances focusing on AIE‐active NIR type I PSs that include the aspects of the photochemical mechanism of type I ROS generation, various molecular structures of reported type I PSs with NIR fluorescence and their design strategies, and typical anticancer applications are summarized. Finally, a brief conclusion is obtained, and the underlying challenges and prospects of AIE‐active type I PSs are proposed.

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Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors

Li,

Yuan,

Zhang

et al. 2024

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Overcoming the resistance of tumor cells to apoptosis and immunosuppression is an important challenge to improve tumor immunotherapy. Non‐apoptotic death mode of ferroptosis has been regarded as a new strategy to enhance tumor immunotherapy against drug‐resistant cancers. The lethal accumulation of lipid peroxides (LPO) determines the progress of ferroptosis. The high susceptibleness of ferroptosis provides an opportunity for combating triple‐negative breast cancer. Reactive nitrogen species (RNS) produced by nitric oxide (NO) and reactive oxygen species (ROS) is more lethal than ROS for tumor cells. Herein, an RNS‐mediated immunotherapy strategy for inducing ferroptosis pathway is proposed by improving LPO accumulation, and constructed a multifunctional liposome (Lipo‐MT‐SNAP) comprised of peroxynitrite (ONOO−) generator, tumor targeted group, inhibiting glutathione peroxidase 4 (GPX4), and basic units (dipalmitoyl phosphatidylcholine and cholesterol). The significant enhancement of LPO resulted from the intense oxidative damage of ONOO− impaired synthesis of GPX4 by depleting glutathione, which further amplified ferroptosis and triggered immunogenic cell death. In vivo, RNS‐mediated photoimmunotherapy can promote polarization of M2 to M1 macrophages and dendritic cells maturation, further infiltrate T cells, regulate the secretion of inflammatory factors, and reprogram the tumor microenvironment. The powerful RNS‐mediated ferroptosis induces strong immunogenicity and effectively inhibit tumor proliferation.

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A targeted phototheranostic agent with strong AIE effect and boosted type I ROS generation

Cited by 6 publications

References 38 publications

Anion‐π⁺ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Anion‐π⁺ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Recent advances in aggregation‐induced emission–active type I photosensitizers with near‐infrared fluorescence: From materials design to therapeutic platform fabrication

Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors

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A targeted phototheranostic agent with strong AIE effect and boosted type I ROS generation

Cited by 6 publications

References 38 publications

Anion‐π+ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Anion‐π+ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Recent advances in aggregation‐induced emission–active type I photosensitizers with near‐infrared fluorescence: From materials design to therapeutic platform fabrication

Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors

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Anion‐π⁺ AIEgens for Fluorescence Imaging and Photodynamic Therapy

Anion‐π⁺ AIEgens for Fluorescence Imaging and Photodynamic Therapy