A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system
Rodrigo Moreno-Campos,
Eileen W. Singleton,
Rosa A. Uribe
Abstract:The vertebrate enteric nervous system (ENS) is a crucial network of enteric neurons and glia resident within the entire gastrointestinal tract (GI). Overseeing essential GI functions such as gut motility and water balance, the ENS serves as a pivotal bidirectional link in the gut-brain axis. During early development, the ENS is primarily derived from enteric neural crest cells (ENCCs). Disruptions to ENCC development, as seen in conditions like Hirschsprung disease (HSCR), lead to absence of ENS in the GI, par… Show more
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