A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening

Fowler, Karen B.; McCollister, Faye P.; Sabo, Diane L.; Shoup, Angela G.; Owen, Kris E.; Woodruff, Julie L.; Cox, Edith; Mohamed, Lisa S.; Choo, Daniel I.; Boppana, Suresh B.

doi:10.1542/peds.2016-2128

Cited by 160 publications

(182 citation statements)

References 30 publications

(19 reference statements)

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…In total, 68 neonates had congenital CMV, and 24 had confirmed SNHL. Overall, 7/24 (29%) of cases of SNHL in Brazil were attributable to CMV, a figure similar to that reported from other countries . What was different from the published literature was that none of 49 babies in the study with congenital CMV who had normal hearing at birth developed SNHL when followed prospectively with serial hearing tests for a median of 36 months .…”

supporting

confidence: 57%

“…CMV is the commonest cause of congenital infection, damages the intellectual potential of as many babies as does Down syndrome, and is the single most common cause of sensorineural hearing loss (SNHL) in children . Performing tests for CMV in those who fail neonatal hearing screening identifies some cases of SNHL but misses the majority, because many CMV cases do not develop SNHL until later in life . Valganciclovir given within a month of birth to babies born with symptoms of congenital CMV infection reduces hearing loss, but this treatment cannot be considered in most cases of congenital infection because only a minority exhibit signs at birth .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Natural history studies bring universal screening for congenital CMV infection closer

Griffiths

2019

Reviews in Medical Virology

View full text Add to dashboard Cite

supporting

confidence: 57%

mentioning

confidence: 99%

Natural history studies bring universal screening for congenital CMV infection closer

Griffiths

2019

Reviews in Medical Virology

View full text Add to dashboard Cite

“…19 Data from the CMV and Hearing Multicenter Screening Study revealed that nearly half of children with asymptomatic congenital CMV infection who are diagnosed with SNHL within 8 weeks of age are missed by newborn hearing screening. 34 Screening of newborns for congenital CMV infection may allow early identification of SNHL in children with asymptomatic congenital CMV infection 34 so that they can receive appropriate interventions to minimize delays in their communication, cognition, reading, and social-emotional development. 35 However, there is currently no consensus on audiologic monitoring for children with asymptomatic congenital CMV infection.…”

Section: Discussionmentioning

confidence: 99%

Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection

Lopez¹,

Lanzieri²,

Claussen³

et al. 2017

Pediatrics

View full text Add to dashboard Cite

Objectives To examine intelligence, language, and academic achievement through 18 years of age among children with congenital CMV infection identified through hospital-based newborn screening who were asymptomatic at birth compared to uninfected infants. Methods We used growth curve modeling to analyze trends in intelligence quotient (full-scale, verbal and non-verbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for case-patients with normal hearing (n=78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age (n=11) and controls (n=40). Results Case-patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared to controls, but no significant differences were noted in these scores among case-patients with normal hearing and controls. No significant differences were noted in scores for verbal and non-verbal intelligence, expressive vocabulary, and academic achievement in math and reading among case-patients with normal hearing or with SNHL and controls. Conclusions Infants with asymptomatic congenital CMV infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in intelligence quotient, vocabulary or academic achievement scores during childhood or adolescence compared with uninfected children.

show abstract

“…However, infants with asymptomatic infection may account for a greater number of SNHL cases. 4 Moreover, an estimated 5% of children with asymptomatic congenital CMV infection -- about 900 children annually in the United States -- have severe hearing loss in at least one ear by age 12 months. 6 Half of these children meet current candidacy criteria for cochlear implantation by age 5 years.…”

Section: Introductionmentioning

confidence: 99%

Hearing Trajectory in Children with Congenital Cytomegalovirus Infection

Lanzieri

Chung

Leung

et al. 2018

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Objectives Compare hearing trajectories among children with symptomatic and asymptomatic congenital CMV infection through age 18 years and identify brain abnormalities associated with sensorineural hearing loss (SNHL) in asymptomatic case-patients. Study Design Longitudinal prospective cohort study. Setting Tertiary medical center. Subjects and Methods Ninety-six (4 symptomatic and 92 asymptomatic) case-patients identified through hospital-based newborn CMV screening during 1982–1992 and 72 symptomatic case-patients identified through referrals during 1993–2005. We used growth curve modeling to analyze hearing thresholds (0.5–8 kHz) by ear with increasing age and Cox regression to determine abnormal findings on head computed tomography (CT) scan associated with SNHL (hearing threshold ≥25 dB in any audiometric frequency) among asymptomatic case-patients. Results Fifty-six (74%) symptomatic and 20 (22%) asymptomatic case-patients had SNHL: congenital/early-onset SNHL was diagnosed in 78 (51%) and 10 (5%) ears, respectively, and delayed-onset SNHL in 25 (17%) and 20 (11%) ears; 49 (32%) and 154 (84%) ears had normal hearing. In affected ears, all frequency-specific hearing thresholds worsened with age. Congenital/early-onset SNHL was significantly worse (severe-profound range [>70dB]) than delayed-onset SNHL (mild-moderate range [26–55db]). Frequency-specific hearing thresholds were significantly different between symptomatic and asymptomatic case-patients at 0.5–1 kHz but not at higher frequencies (2–8 kHz). Among asymptomatic case-patients, white matter lucency was significantly associated with SNHL by age 5 years (hazard ratio=4.4; 95% confidence interval: 1.3–15.6). Conclusion Congenital/early-onset SNHL frequently resulted in severe to profound loss in both symptomatic and asymptomatic case-patients. White matter lucency in asymptomatic case-patients was significantly associated with SNHL by age 5 years.

show abstract

A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening

Abstract: A targeted CMV approach that tests newborns who fail their NHS identified the majority of infants with CMV-related SNHL at birth. However, 43% of the infants with CMV-related SNHL in the neonatal period and cCMV infants who are at risk for late onset SNHL were not identified by NHS.

Cited by 160 publications

References 30 publications

Natural history studies bring universal screening for congenital CMV infection closer

Natural history studies bring universal screening for congenital CMV infection closer

Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection

Hearing Trajectory in Children with Congenital Cytomegalovirus Infection

Contact Info

Product

Resources

About