A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System

Coiffard, Benjamin; Diallo, Aïssatou Bailo; Mezouar, Soraya; Léone, Marc; Mège, Jean‐Louis

doi:10.3390/biology10010065

Cited by 43 publications

(37 citation statements)

References 117 publications

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“…The main mechanisms for developing otitis media in obese patients include gastroesophageal reflux and/or alteration in cytokine profile [29]. The importance of circadian rhythm in the pathophysiology of diseases of the airways that are subject to systemic inflammation such as chronic obstructive pulmonary disease, chronic sinusitis, idiopathic pulmonary fibrosis or asthma, has been reported many times [30]. The inclusion of otitis in this select group, therefore, should be given serious consideration.…”

Section: Discussionmentioning

confidence: 99%

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Díez¹,

Verd²,

Ponce‐Taylor³

et al. 2022

Preprint

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Running at odds with the timing imposed by the circadian clock plays an important role in the process that leads to communicable and non communicable diseases. The primary objective of this study was to analyse whether early dinner eater children were at lower risks of acute respiratory infections than late dinner eater children, during the COVID-19 pandemic. Methods: This cross sectional study was conducted from July to December 2020 on children attending Majorcan emergency services. Clinical data collected included timing, symptoms, laboratory tests and imaging studies of current illness. Each diagnosis was validated by general paediatricians. Our survey on dinner time habits was carried out by using self-administered questionnaires. Results: A total of 669 children under age 18 were included in the study. The median of dinner time was 8:30 pm. Late dinner eaters accounted for a higher proportion of acute otitis media than early dinner eaters (7% vs 3%; P=0.028). Other infectious diseases were not associated with dinner time habits. Conclusions: We make a preliminary estimate of the link between late dinner habits and acute otitis media in children. However, no conclusions about causality can be established due to the observational design of the study.

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Section: Discussionmentioning

confidence: 99%

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Díez¹,

Verd²,

Ponce‐Taylor³

et al. 2022

Preprint

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“…In fact, there is a programed, significant cyclic variation on the order of 1 C over the 24-h period of each day that far exceeds the control tolerance of thermoregulation [34,[40][41][42]. Of course, it is well known that the circadian cycle has a much broader physiological impact than just thermoregulation, effecting sleep, metabolism, immunity, physical performance capability, behavioral function, and the list goes on and on [43,44]. It is interesting that the thermoregulation circadian rhythm has a leading effect in directing many of the other circadian-oriented phenomena, including sleep [45][46][47][48].…”

Section: And Thementioning

confidence: 99%

Bioheat Transfer Basis of Human Thermoregulation: Principles and Applications

Namisnak

Haghayegh

Khoshnevis

et al. 2022

Journal of Heat Transfer

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Thermoregulation is a process that is essential to the maintenance of life for all warm-blooded mammalian and avian species. It sustains a constant core body temperature in the face of a wide array of environmental thermal conditions and intensity of physical activities that generate internal heat. A primary component of thermoregulatory function is the movement of heat between the body core and the surface via the circulation of blood. The peripheral vasculature acts as a forced convection heat exchanger between blood and local peripheral tissues enabling heat to be conducted to the skin surface where is may be transferred to and from the environment via conduction, convection, radiation, and/or evaporation of water as local conditions dictate. Humans have evolved a particular vascular structure in glabrous (hairless) skin that is especially well suited for heat exchange. These vessels are called arteriovenous anastomoses (AVAs) and can vasodilate to large diameters and accommodate high flow rates. We report herein a new technology based on a physiological principle that enables simple and safe access to the thermoregulatory control system that allow manipulation of thermoregulatory function. The technology operates by applying a small amount of heating local to control tissue on the body surface overlying the cerebral spine that upregulates AVA perfusion. Under this action, heat exchangers can be applied to glabrous skin, preferably on the palms and soles, to alter the temperature of elevated blood flow prior to its return to the core. Therapeutic and prophylactic applications are discussed.

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“…Core temperature is critical for governing the essential functions of the body and should be maintained near 37 °C 27 . It typically fluctuates within 1 °C according to circadian rhythm 28 , but can reach ~40 °C amid strenuous workload or ~35.6 °C in extremely cold environments 29 . A significant deviation of the core temperature indicates failing thermoregulation 27 with dire consequences [30][31][32][33] , sometimes life-threatening 34 .…”

Section: Ex-vivo Core Temperature Mapping and Validationmentioning

confidence: 99%

A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

Gao¹,

Chen²,

Hu³

et al. 2021

Preprint

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Electronic patches, based on various mechanisms, allow continuous and noninvasive monitoring of biomolecules on the skin surface. However, to date, such devices have been unable to sense biomolecules in deep tissues, which have a stronger and faster correlation with the human physiological status. Here, we demonstrate a photoacoustic patch for three-dimensional (3D) mapping of hemoglobin in deep tissues. This photoacoustic patch integrates an array of ultrasonic transducers and vertical-cavity surface-emitting laser (VCSEL) diodes on a common soft substrate. The high-power VCSEL diodes can generate laser pulses that penetrate >2 cm into human tissues and activate hemoglobin molecules to generate acoustic waves, which can be collected by the transducers for 3D imaging of the hemoglobin with a sub-millimeter spatial resolution. Additionally, the photoacoustic signal amplitude and temperature have a linear relationship, which allows 3D mapping of core temperatures with high accuracy and fast response. The results of 3D core temperature mapping and long-term monitoring in ex-vivo and in-vivo studies are validated by commercial devices. With access to biomolecules in deep tissues, this technology adds unprecedented functions to wearable electronics and thus holds significant implications for various applications in both basic research and clinical practice.

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A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System

Cited by 43 publications

References 117 publications

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Bioheat Transfer Basis of Human Thermoregulation: Principles and Applications

A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

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