2021
DOI: 10.3390/biology10010065
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A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System

Abstract: The circadian rhythm of the body temperature (CRBT) is a marker of the central biological clock that results from multiple complex biological processes. In mammals, including humans, the body temperature displays a strict circadian rhythm and has to be maintained within a narrow range to allow optimal physiological functions. There is nowadays growing evidence on the role of the temperature circadian rhythm on the expression of the molecular clock. The CRBT likely participates in the phase coordination of circ… Show more

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Cited by 43 publications
(37 citation statements)
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“…The main mechanisms for developing otitis media in obese patients include gastroesophageal reflux and/or alteration in cytokine profile [29]. The importance of circadian rhythm in the pathophysiology of diseases of the airways that are subject to systemic inflammation such as chronic obstructive pulmonary disease, chronic sinusitis, idiopathic pulmonary fibrosis or asthma, has been reported many times [30]. The inclusion of otitis in this select group, therefore, should be given serious consideration.…”
Section: Discussionmentioning
confidence: 99%
“…The main mechanisms for developing otitis media in obese patients include gastroesophageal reflux and/or alteration in cytokine profile [29]. The importance of circadian rhythm in the pathophysiology of diseases of the airways that are subject to systemic inflammation such as chronic obstructive pulmonary disease, chronic sinusitis, idiopathic pulmonary fibrosis or asthma, has been reported many times [30]. The inclusion of otitis in this select group, therefore, should be given serious consideration.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, there is a programed, significant cyclic variation on the order of 1 C over the 24-h period of each day that far exceeds the control tolerance of thermoregulation [34,[40][41][42]. Of course, it is well known that the circadian cycle has a much broader physiological impact than just thermoregulation, effecting sleep, metabolism, immunity, physical performance capability, behavioral function, and the list goes on and on [43,44]. It is interesting that the thermoregulation circadian rhythm has a leading effect in directing many of the other circadian-oriented phenomena, including sleep [45][46][47][48].…”
Section: And Thementioning
confidence: 99%
“…Core temperature is critical for governing the essential functions of the body and should be maintained near 37 °C 27 . It typically fluctuates within 1 °C according to circadian rhythm 28 , but can reach ~40 °C amid strenuous workload or ~35.6 °C in extremely cold environments 29 . A significant deviation of the core temperature indicates failing thermoregulation 27 with dire consequences [30][31][32][33] , sometimes life-threatening 34 .…”
Section: Ex-vivo Core Temperature Mapping and Validationmentioning
confidence: 99%