A tangential neuronal migration in the olfactory bulbs of adult lizards

Peñafiel, Antonio; Gutiérrez, Antonia; Martín, Rosa Echarri San; Pérez-Cañellas, Mar; Calle, Adélaïda de la

doi:10.1097/00001756-199605170-00007

Cited by 17 publications

(15 citation statements)

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“…In mature doves, it has been reported that new neurons are dispersed into the forebrain without any particular clustering (Ling et al 1997). Evidence for long-distance tangential migration from the telencephalic ventricular zone into the olfactory bulb has been found in reptiles, even though proliferation inherent to the olfactory bulb is also present (Penafiel et al 1996;Pérez-Canellas et al 1997;Font et al 2001). In amphibians, there are no detailed studies of tangential migration in the telencephalon, though proliferation has been reported in the ventral telencephalon of salamanders and frogs.…”

Section: (D) Reptilesmentioning

confidence: 99%

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Kaslin

Ganz

Brand

2007

Phil. Trans. R. Soc. B

314

302

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Post-embryonic neurogenesis is a fundamental feature of the vertebrate brain. However, the level of adult neurogenesis decreases significantly with phylogeny. In the first part of this review, a comparative analysis of adult neurogenesis and its putative roles in vertebrates are discussed. Adult neurogenesis in mammals is restricted to two telencephalic constitutively active zones. On the contrary, non-mammalian vertebrates display a considerable amount of adult neurogenesis in many brain regions. The phylogenetic differences in adult neurogenesis are poorly understood. However, a common feature of vertebrates (fish, amphibians and reptiles) that display a widespread adult neurogenesis is the substantial post-embryonic brain growth in contrast to birds and mammals. It is probable that the adult neurogenesis in fish, frogs and reptiles is related to the coordinated growth of sensory systems and corresponding sensory brain regions. Likewise, neurons are substantially added to the olfactory bulb in smell-oriented mammals in contrast to more visually oriented primates and songbirds, where much fewer neurons are added to the olfactory bulb. The second part of this review focuses on the differences in brain plasticity and regeneration in vertebrates. Interestingly, several recent studies show that neurogenesis is suppressed in the adult mammalian brain. In mammals, neurogenesis can be induced in the constitutively neurogenic brain regions as well as ectopically in response to injury, disease or experimental manipulations. Furthermore, multipotent progenitor cells can be isolated and differentiated in vitro from several otherwise silent regions of the mammalian brain. This indicates that the potential to recruit or generate neurons in non-neurogenic brain areas is not completely lost in mammals. The level of adult neurogenesis in vertebrates correlates with the capacity to regenerate injury, for example fish and amphibians exhibit the most widespread adult neurogenesis and also the greatest capacity to regenerate central nervous system injuries. Studying these phenomena in non-mammalian vertebrates may greatly increase our understanding of the mechanisms underlying regeneration and adult neurogenesis. Understanding mechanisms that regulate endogenous proliferation and neurogenic permissiveness in the adult brain is of great significance in therapeutical approaches for brain injury and disease.

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Section: (D) Reptilesmentioning

confidence: 99%

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Kaslin

Ganz

Brand

2007

Phil. Trans. R. Soc. B

314

302

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“…The cells generated there migrate longitudinally until the olfactory bulb (Peñafiel et al 1996), where they differentiate and become incorporated in the olfactory bulb circuitry.…”

Section: The Lizard Neural Stem Cells and The Ependymal Sulcimentioning

confidence: 99%

The lizard cerebral cortex as a model to study neuronal regeneration

López‐García

Molowny

Nácher

et al. 2002

An. Acad. Bras. Ciênc.

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The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zincenriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.

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“…In mammals, the RMS is well known as a highly neurogenerative and neuromigratory region, and has been given the name, "Rostral Migratory Stream," because it is where neuronal precursors migrate from the ependymal zone to the olfactory bulb. The findings of this study confirm studies in other reptiles (Peñafiel et al, 1996;Pérez-Cañellas et al, 1997), indicating the presence of a RMS similar to that of fish (Grandel et al, 2006) and mammals (Pencea et al, 2001). There is no evidence indicating an RMS in amphibians or humans, and limited evidence in birds (Kaslin et al, 2008).…”

Section: Olfaction and The Rmssupporting

confidence: 86%

“…There has been limited evidence that cells born in the sulcus ventrails/terminals tangentially migrate from the rostral forebrain to the OB in T. mauritanica, Podarcis sicula, Psammodromus algirus (the large psammodromus), and turtles (Font et al, 2001;Margotta et al, 1999;Peñafiel et al, 1996;Pérez-Cañellas and García-Verdugo, 1996). While this process is considered similar to the mammalian rostral migratory stream (RMS), the similarities still have only been investigated on a superficial level.…”

Section: General Comparisonsmentioning

confidence: 99%

Proliferation, Migration, and Survival of Cells in the Telencephalon of the Ball Python, Python Regius

Bales¹

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A tangential neuronal migration in the olfactory bulbs of adult lizards

Cited by 17 publications

References 0 publications

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

The lizard cerebral cortex as a model to study neuronal regeneration

Proliferation, Migration, and Survival of Cells in the Telencephalon of the Ball Python, Python Regius

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