A tandem mass tag (TMT) proteomic analysis during the early phase of experimental pancreatitis reveals new insights in the disease pathogenesis

Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance

“…In its turn, lysosomal cysteine protease cathepsin B appears to be an important factor in the activation of trypsinogen to trypsin [62]. This model has also been used in the study of the identification of new protein alterations and biomarkers [63] characterizing pancreatic inflammatory damage with proteomic [64] and metabolomic [65] analysis. The advantages of this model are its noninvasiveness, inexpensiveness, rapid induction, and wide reproducibility and applicability.…”

Data for Tandem Mass Tag (TMT) proteomic analysis of the pancreas during the early phase of experimental pancreatitis

“…The data reported here includes a shotgun proteomic experiment involving sixplex Tandem Mass Tag (TMT 6 ) labeling that allowed the simultaneous identification and quantification of the early phase of AP proteome from the soluble and the whole membrane pancreatic fractions from three AP and three control animals [1] .…”

“…We identified 997 unique proteins, of which 353 were significantly different (22, 276 or 55 in both, the soluble or the membrane fractions, respectively). Accordingly, using TMT proteomics and bioinformatic tools, in García-Hernández et al, 2018- [1] we were able to detect significant changes in protein expression related to many pathobiological pathways of AP as from the early phase of the disease, including some changes never described before in this disease. Proteomics data are publicly available in ProteomeXchange via PRIDE through the identifier PXD007096.…”

“… The quantitative proteomics data reported here pertain to the research article entitled “A Tandem Mass Tag (TMT) proteomic analysis during the early phase of experimental pancreatitis reveals new insights in the disease pathogenesis” (García-Hernández et al, 2018) [1] . The development of acute pancreatitis (AP, an important pathological inflammatory state of the exocrine pancreas) would be based on early changes in protein expression and signaling pathways whose unmasking would be crucial for deciphering AP at the molecular level.…”

“…The quantitative proteomics data reported here pertain to the research article entitled “A Tandem Mass Tag (TMT) proteomic analysis during the early phase of experimental pancreatitis reveals new insights in the disease pathogenesis” (García-Hernández et al, 2018) [1] .…”