A tale of two vulvar angiomyxomas: Two cases and review of literature

Nodular Vulvar Lesions

“…It is characterized by deep subcutaneous nodules most commonly in the head or neck, often accompanied by regional lymph node involvement, hypereosinophilia in peripheral blood, and elevated total immunoglobulin E. Histologically, Kimura disease mainly shows hyperplastic lymphoid follicles with prominent germinal centers surrounded by abundant eosinophils . Angiomyxomas are rare, benign mesenchymal neoplasms with 2 phenotypes: superficial (or cutaneous) and aggressive (or deep) angiomyxomas, both of which can involve the vulva and present as a slow-growing mass . The most important pathological features are stellate and spindle-shaped tumor cells set in a loose myxoid stroma accompanied by numerous blood vessels, ranging from tiny capillarylike vessels to larger thick-walled vessels with a distinct smooth muscle layer .…”