A tale of two phage tails: Engineering the host range of bacteriophages infectingClostridioides difficile
Joanna P. Steczynska,
Sarah J. Kerr,
Michelle L. Kelly
et al.
Abstract:Clostridioides difficile infection (CDI) is a leading cause of antibiotic-associated diarrhoea across the globe. Although treatable with a restricted number of antibiotics, the emergence of resistant variants and high relapse rates necessitate alternative countermeasures. Phage therapy represents an attractive option. However, its implementation is handicapped by the narrow host specificity of the C. difficile bacteriophages isolated to date. One strategy to rationally expand phage host range would be to make … Show more
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