A Tale of Two Elabela Null Mice

Papangeli, Irinna; Chun, Hyung J.

doi:10.1016/j.tem.2017.09.004

Cited by 2 publications

(1 citation statement)

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“…Loss of APJ leads to abnormal development of myocardial progenitor and defects in heart development ( 50 , 51 ). Apela is an endogenous ligand of APJ newly discovered in recent years ( 141 ), and the absence of apela gene also leads to early deformation of heart development ( 142 , 143 ). Many other GPCRs are also important in heart development.…”

Section: Gpcrs In Heart Function and Diseasementioning

confidence: 99%

Role of G-protein coupled receptors in cardiovascular diseases

Li²,

Chen

et al. 2023

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an essential regulating cellular physiology and pathology. Some GPCR antagonists, such as β-blockers, are standard therapy for the treatment of CVDs. In addition, nearly one-third of the drugs used to treat CVDs target GPCRs. All the evidence demonstrates the crucial role of GPCRs in CVDs. Over the past decades, studies on the structure and function of GPCRs have identified many targets for the treatment of CVDs. In this review, we summarize and discuss the role of GPCRs in the function of the cardiovascular system from both vascular and heart perspectives, then analyze the complex ways in which multiple GPCRs exert regulatory functions in vascular and heart diseases. We hope to provide new ideas for the treatment of CVDs and the development of novel drugs.

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