A tale of two diseases: The history of inflammatory bowel disease

Mulder, Daniel J.; Noble, Angela; Justinich, Christopher J.; Duffin, Jacalyn

doi:10.1016/j.crohns.2013.09.009

Cited by 164 publications

(120 citation statements)

References 69 publications

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“…IBD affects millions of people worldwide, and is significantly associated with colorectal cancer (CRC) risk, whose incidence is now rapidly increasing in previously risk-free continents, such as Asia and South America, due to westernized diets22. Although UC and CD have similar clinical pathologic characteristics, they also have marked differences, such as disease course and immunological genotype2324.…”

Section: Discussionmentioning

confidence: 99%

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Jin

Chung

Cheon

et al. 2017

Sci Rep

138

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Ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), is a chronic inflammatory disorder of the colon. Although UC is generally treated with anti-inflammatory drugs or immunosuppressants, most of these treatments often prove to be inadequate. Rosmarinic acid (RA) is a phenolic ester included in various medicinal herbs such as Salvia miltiorrhiz and Perilla frutescens. Although RA has many biological and pharmacological activities, the anti-inflammatory effect of RA in colonic tissue remains unclear. In this study, we investigated the anti-inflammatory effects and underlying molecular mechanism of RA in mice with dextran sulphate sodium (DSS)-induced colitis. In the DSS-induced colitis model, RA significantly reduced the severity of colitis, as assessed by disease activity index (DAI) scores, colonic damage, and colon length. In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1β, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis. Furthermore, RA effectively and pleiotropically inhibited nuclear factor-kappa B and signal transducer and activator of transcription 3 activation, and subsequently reduced the activity of pro-survival genes that depend on these transcription factors. These results demonstrate that RA has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.

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Section: Discussionmentioning

confidence: 99%

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Jin

Chung

Cheon

et al. 2017

Sci Rep

138

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“…Ulcerative colitis (UC) and Crohn’s disease (CD) are two typical forms of inflammatory intestinal disease belonging to inflammatory bowel disease (IBD) [1], which affect millions of people worldwide and carry a widespread health hazard in modern society [2]. IBD is characterized by chronic and recurrent inflammatory disorders of the gastrointestinal tract [3].…”

Section: Introductionmentioning

confidence: 99%

The Algal Meroterpene 11-Hydroxy-1′-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice

et al. 2016

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Inflammatory bowel disease (IBD) is a complex class of immune disorders. Unfortunately, a treatment for total remission has not yet been found, while the use of natural product-based therapies has emerged as a promising intervention. The present study was aimed to investigate the anti-inflammatory effects of the algal meroterpene 11-hydroxy-1′-O-methylamentadione (AMT-E) in a murine model of dextran sodium sulphate (DSS)-induced colitis. AMT-E was orally administered daily (1, 10, and 20 mg/kg animal) to DSS treated mice (3% w/v) for 7 days. AMT-E prevented body weight loss and colon shortening and effectively attenuated the extent of the colonic damage. Similarly, AMT-E increased mucus production and reduced myeloperoxidase activity (marker for anti-inflammatory activity). Moreover, the algal meroterpene decreased the tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-10 levels, and caused a significant reduction of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Our results demonstrate the protective effects of AMT-E on experimental colitis, provide an insight of the underlying mechanisms of this compound, and suggest that this class of marine natural products might be an interesting candidate for further studies on the prevention/treatment of IBD.

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“…These illnesses become chronic at an early stage and are characterized by periods of remission and exacerbations. 1 In addition to their burdensome intestinal manifestations, both CD and UC present with a wide range of systemic manifestations, including constitutional symptoms, arthritis, weight loss, fever, and uveitis.…”

Section: Introductionmentioning

confidence: 99%

Religious coping and its influence on psychological distress, medication adherence, and quality of life in inflammatory bowel disease

Freitas

Hyphantis

Andreoulakis

et al. 2015

Braz. J. Psychiatry

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Objective: Inflammatory bowel disease (IBD) is associated with elevated levels of anxiety and depression and a reduction in health-related quality of life (HRQoL). Nonadherence to treatment is also frequent in IBD and compromises outcomes. Religious coping plays a role in the adaptation to several chronic diseases. However, the influence of religious coping on IBD-related psychological distress, HRQoL, and treatment adherence remains unknown. Method: This cross-sectional study recruited 147 consecutive patients with either Crohn's disease or ulcerative colitis. Sociodemographic data, disease-related variables, psychological distress (Hospital Anxiety and Depression Scale), religious coping (Brief RCOPE Scale), HRQoL (WHOQOL-Bref), and adherence (8-item Morisky Medication Adherence Scale) were assessed. Hierarchical multiple regression models were used to evaluate the effects of religious coping on IBD-related psychological distress, treatment adherence, and HRQoL. Results: Positive RCOPE was negatively associated with anxiety (b = -0.256; p = 0.007) as well as with overall, physical, and mental health HRQoL. Religious struggle was significantly associated with depression (b = 0.307; p o 0.001) and self-reported adherence (b = -0.258; p = 0.009). Finally, anxiety symptoms fully mediated the effect of positive religious coping on overall HRQoL. Conclusion: Religious coping is significantly associated with psychological distress, HRQoL, and adherence in IBD.

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A tale of two diseases: The history of inflammatory bowel disease

Cited by 164 publications

References 69 publications

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

The Algal Meroterpene 11-Hydroxy-1′-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice

Religious coping and its influence on psychological distress, medication adherence, and quality of life in inflammatory bowel disease

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