A tale of exosomes and their implication in cancer

Mishra, Abhay Kumar; Bharti, Prahalad Singh; Rani, Neha; Nikolajeff, Fredrik; Kumar, Saroj

doi:10.1016/j.bbcan.2023.188908

Cited by 13 publications

(5 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the rapid progress in the analytical technique of exosome [ 45 , 46 ], the dissection of the roles that exosomes play in the tumor biology has received much attention [ 5 , 6 ]. Exosomes are now emerging as pivotal regulators of most if not all hallmarks of cancer [ 47 ].…”

Section: Tumor Biology Of Exosomesmentioning

confidence: 99%

“…Moreover, in bladder cancer, CAFs-derived miR-146a-5p was demonstrated to foster CSC niche formation and cancer stemness to drive chemoresistance via co-targeting ARID1A and PRKAA2 (also known as AMPKα2) [ 89 ]. Given these findings, the therapeutic strategy to overcome drug resistance through targeting exosomes-induced EMT and CSCs is attracting much interest [ 47 , 359 ].…”

Section: Tumor Biology Of Exosomesmentioning

confidence: 99%

See 1 more Smart Citation

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Wu,

Cao,

Chen

et al. 2024

Biol Proced Online

View full text Add to dashboard Cite

Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer cells as well as cellular components in tumor microenvironment. After secretion, the exosomes carrying a wide range of bioactive cargos can be ingested by local or distant recipient cells. The released cargos act through a variety of mechanisms to elicit multiple biological effects and impact most if not all hallmarks of cancer. Moreover, owing to their excellent biocompatibility and capability of being easily engineered or modified, exosomes are currently exploited as a promising platform for cancer targeted therapy. In this review, we first summarize the current knowledge of roles of exosomes in risk and etiology, initiation and progression of cancer, as well as their underlying molecular mechanisms. The aptamer-modified exosome as a promising platform for cancer targeted therapy is then briefly introduced. We also discuss the future directions for emerging roles of exosome in tumor biology and perspective of aptamer-modified exosomes in cancer therapy.

show abstract

Section: Tumor Biology Of Exosomesmentioning

confidence: 99%

Section: Tumor Biology Of Exosomesmentioning

confidence: 99%

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Wu,

Cao,

Chen

et al. 2024

Biol Proced Online

View full text Add to dashboard Cite

show abstract

“…In this review, we delve into specific characteristics of sEVs that remain relatively unexplored but contribute significantly to their biological activity. Let’s explore the fascinating world of EVs beyond their molecular content 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic insight into breast cancer: profiling small extracellular vesicles lipids via infrared spectroscopy for diagnostic precision

Mishra,

Zehra,

Bharti

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

Breast cancer, a leading cause of female mortality due to delayed detection owing to asymptomatic nature and limited early diagnostic tools, was investigated using a multi-modal approach. Plasma-derived small EVs from breast cancer patients (BrCa, n = 74) and healthy controls (HC, n = 30) were analyzed. Small EVs (n = 104), isolated through chemical precipitation, underwent characterization via transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). Validation involved antibody-based tests (TSG101, CD9, CD81, CD63). Infrared spectra of small EVs were obtained, revealing significant differences in lipid acyl chains, particularly in the C–H stretching of CH3. The study focused on the lipid region (3050–2900 cm−1), identifying peaks (3015 cm−1, 2960 cm−1, 2929 cm−1) as distinctive lipid characteristics. Spectroscopic lipid-to-lipid ratios [(I3015/I2929), (I2960/I2929)] emerged as prominent breast cancer markers. Exploration of protein, nucleic acid, and carbohydrate ratios indicated variations in alpha helices, asymmetric C–H stretching vibrations, and C–O stretching at 1033 cm−1. Principal component analysis (PCA) successfully differentiated BrCa and HC small EVs, and heatmap analysis and receiver operating characteristic (ROC) curve evaluations underscored the discriminatory power of lipid ratios. Notably, (I2960/I2929) exhibited 100% sensitivity and specificity, highlighting its potential as a robust BrCa sEV marker for breast cancer detection.

show abstract

“…Exosomes are extracellular vesicles between 30-150 nm in diameter with a phospholipid bilayer composed of various proteins, lipids and nucleic acids ( 14 ). The phospholipid bilayer protects protect the material within the exosome from removal or degradation.…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer

Han,

Zhang,

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common malignancies worldwide and the leading cause of cancer-related deaths. Exosomes are nanoscale extracellular vesicles secreted by a variety of cells and play an important role in cellular communication and epigenetics by transporting bioactive substances in the tumor microenvironment (TME). Circular RNA (circRNA) is a type of non-coding RNA (ncRNA) with a specific structure, which is widely enriched in exosomes and is involved in various pathophysiological processes mediated by exosomes. Exosomal circRNAs play a critical role in the development of GC by regulating epithelial-mesenchymal transition (EMT), angiogenesis, proliferation, invasion, migration, and metastasis of GC. Given the biological characteristics of exosomal circRNAs, they have more significant diagnostic sensitivity and specificity in the clinic and may become biomarkers for GC diagnosis and prognosis. In this review, we briefly describe the biogenesis of exosomes and circRNAs and their biological functions, comprehensively summarize the mechanisms of exosomal circRNAs in the development of GC and chemotherapy resistance, and finally, we discuss the potential clinical application value and challenges of exosomal circRNAs in GC.

show abstract

A tale of exosomes and their implication in cancer

Cited by 13 publications

References 217 publications

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Spectroscopic insight into breast cancer: profiling small extracellular vesicles lipids via infrared spectroscopy for diagnostic precision

Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer

Contact Info

Product

Resources

About