Abstract:Pseudomonas aeruginosa is a difficult-to-treat Gram-negative bacterial
pathogen causing life-threatening infections. Adaptive resistance (AR)
to cationic peptide antibiotics such as polymyxin B impairs the
therapeutic success. This self-protection is mediated by two component
systems (TCS) consisting of a membrane-bound histidine kinase and an
intracellular response regulator (RR). As phosphorylation of the key RR
aspartate residue is transient during signaling and hydrolytically
unstable, the study of … Show more
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