A “tail” of opioid receptor variants

Puig, Stéphanie; Gutstein, Howard B.

doi:10.1172/jci93582

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Importantly, in vivo functions of several C-terminal variants were recently revealed in C-terminal truncation mouse models with two inbred mouse background (Xu et al, 2017). Particularly, exon 7 (E7)-associated C-terminal truncation in C57BL/6J strain (mE7M-B6) diminished morphine tolerance and reward without altering physical dependence, whereas the E4-associated C-terminal truncation (mE4M-B6) accelerated morphine tolerance and reduced morphine dependence without affecting morphine reward (Puig & Gutstein, 2017;Xu et al, 2017), highlighting the importance of the C-terminal sequences in morphine actions.…”

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confidence: 99%

Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self‐administering male rats

Brown

Hurd

et al. 2020

J of Neuroscience Research

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Heroin is a highly addictive drug that has led to the death of numerous people and caused tremendous economic, health-care, and societal costs. The mu opioid receptor gene (OPRM1) is a prominent candidate gene in the underlying neurobiology of heroin addiction. The OPRM1 undergoes extensive alternative splicing, generating multiple splice isoforms or variants that are conserved across species including rodents and humans (Pan, 2005; Pasternak & Pan, 2013). These splice variants can be categorized into three main types based on the predicted receptor structure: (a) Full-length 7 transmembrane (TM) C-terminal variants that are identical except for a different

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confidence: 99%