A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

Booth, Daniel G; Hood, Fiona E.; Prior, Ian A.; Royle, Stephen

doi:10.1038/emboj.2011.15

Cited by 149 publications

(313 citation statements)

References 53 publications

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“…However, another recent paper by Royle and colleagues reported that, although the ablation of clathrin reduced TACC3 targeting to the spindle, the depletion of TACC3 also dramatically resulted in the reduced spindle localization of clathrin [18]. Similar to the previous report [17], they also observed that overexpression of TACC3 results in the accumulation of clathrin at the spindle [18].…”

Section: Clathrin and Mitotic Spindle Assemblysupporting

confidence: 76%

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Novel functions of endocytic player clathrin in mitosis

Jiang

Zhang

2011

Cell Res

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Clathrin has been widely recognized as a pivotal player in endocytosis, in which several adaptors and accessory proteins are involved. Recent studies suggested that clathrin is also essential for cell division. Here this review mainly focuses on the clathrin-dependent mechanisms involved in spindle assembly and chromosome alignment. In mitosis, clathrin forms a complex with phosphorylated TACC3 to ensure spindle stability and proper chromosome alignment. The clathrin-regulated mechanism in mitosis requires the crosstalk among clathrin, spindle assembly factors (SAFs), Ran-GTP and mitotic kinases. Meanwhile, a coordinated mechanism is required for role transitions of clathrin during endocytosis and mitosis. Taken together, the findings of the multiple functions of clathrin besides endocytosis have expanded our understanding of the basic cellular activities.

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Section: Clathrin and Mitotic Spindle Assemblysupporting

confidence: 76%

“…More recently, the role of clathrin in mitosis has been widely recognized. Several individual groups including ours have shed novel lights on the function of clathrin in mitosis at the molecular level [15][16][17][18]. These studies demonstrated that clathrin forms a complex with TACC3 to regulate spindle assembly and chromosome alignment.…”

mentioning

confidence: 99%

Novel functions of endocytic player clathrin in mitosis

Jiang

Zhang

2011

Cell Res

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“…TACC3 has been the most heavily studied of the TACC family members, but a number of reports in the last decade have also begun to unravel some aspects of TACC1 functionality. For example, TACC1 is similar to TACC3 in that it interacts with the C‐terminus of the MT polymerase, ch‐TOG [Booth et al, 2011; Lauffart et al, 2002]. This begs the question of whether TACC1 localizes to the MT plus‐end, as do both TACC3 and ch‐TOG/XMAP215.…”

Section: Introductionmentioning

confidence: 99%

Xenopus TACC1 is a microtubule plus‐end tracking protein that can regulate microtubule dynamics during embryonic development

et al. 2015

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Microtubule plus‐end dynamics are regulated by a family of proteins called plus‐end tracking proteins (+TIPs). We recently demonstrated that the transforming acidic coiled‐coil (TACC) domain family member, TACC3, can function as a +TIP to regulate microtubule dynamics in Xenopus laevis embryonic cells. Although it has been previously reported that TACC3 is the only TACC family member that exists in Xenopus, our examination of its genome determined that Xenopus, like all other vertebrates, contains three TACC family members. Here, we investigate the localization and function of Xenopus TACC1, the founding member of the TACC family. We demonstrate that it can act as a +TIP to regulate microtubule dynamics, and that the conserved C‐terminal TACC domain is required for its localization to plus‐ends. We also show that, in Xenopus embryonic mesenchymal cells, TACC1 and TACC3 are each required for maintaining normal microtubule growth speed but exhibit some functional redundancy in the regulation of microtubule growth lifetime. Given the conservation of TACC1 in Xenopus and other vertebrates, we propose that Xenopus laevis is a useful system to investigate unexplored cell biological functions of TACC1 and other TACC family members in the regulation of microtubule dynamics. © 2015 The Authors. Cytoskeleton, Published by Wiley Periodicals, Inc.

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“…Furthermore, clathrin must be trimeric for the CHC17-TACC3-chTOG complex to be active (28). The CHC17-TACC3-chTOG complex also plays a role in maintaining the stability of the centrosome in mammalian cells (26,28). The removal of CHC17 from the CHC17-TACC3-chTOG complex is devastating, ending in centrosome fragmentation (26).…”

Section: Centrosome and Mitotic Spindle Integritymentioning

confidence: 99%

“…Clathrin must play an important role in the CHC17-TACC3-chTOG complex because K-fibers develop defects when CLC is cross-linked in S phase to inactivate CHC17 (26). Furthermore, clathrin must be trimeric for the CHC17-TACC3-chTOG complex to be active (28). The CHC17-TACC3-chTOG complex also plays a role in maintaining the stability of the centrosome in mammalian cells (26,28).…”

Section: Centrosome and Mitotic Spindle Integritymentioning

confidence: 99%

Novel clathrin activity: developments in health and disease

Ybe

2014

Biomolecular Concepts

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Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health and disease. Clathrin is used to strengthen centrosomes and mitotic spindles essential for chromosome segregation in cell division. In Wnt signaling, clathrin is a component of signalosomes on the plasma membrane needed to produce functional Wnt receptors. In glucose metabolism, a muscle-specific isoform, CHC22 clathrin, is key to the formation of storage compartments for GLUT4 receptor, and CHC22 dysfunction has been tied to type 2 diabetes. The activity of clathrin to self-assemble and to work with huntingtin-interacting proteins to organize actin is exploited by Listeria and enteropathic Escherichia coli in their infection pathways. Finally, there is an important connection between clathrin and human malignancies. Clathrin is argued to help transactivate tumor suppressor p53 that controls specific genes in DNA repair and apoptosis. However, this is debatable because trimeric clathrin must be made monomeric. To get insight on how the clathrin structure could be converted, the crystal structure of the trimerization domain is used in the development of the detrimerization switch hypothesis. This novel hypothesis will be relevant if connections continue to be found between CHC17 and p53 anti-cancer activity in the nucleus.

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A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

Cited by 149 publications

References 53 publications

Novel functions of endocytic player clathrin in mitosis

Novel functions of endocytic player clathrin in mitosis

Xenopus TACC1 is a microtubule plus‐end tracking protein that can regulate microtubule dynamics during embryonic development

Novel clathrin activity: developments in health and disease

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