A tablet that shifts the clock

Gelder, Russell N. Van

doi:10.1073/pnas.1423498112

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…A recent study showed that reading a printed book under reflected light has a significant positive impact on restorative sleep, morning alertness and the circadian cycle compared to reading a book from a light-emitting eReader [ 29 ]. Based on our results and other supporting literature [ 29 , 30 ], we recommend that children should not have access EECDs in their bedroom, and should refrain from using EECDs during the hour before sleep. Instead, parents should encourage children to read a book, preferably printed and with dim lighting, during the hour before sleep.…”

Section: Discussionsupporting

confidence: 70%

“…The backlight of many EECDs currently being manufactured emits diodes rich in blue light. Exposure to blue light close to bedtime suppresses the release of the sleep-facilitating hormone; melatonin, thereby delaying sleep onset, shortening total sleep duration and affecting good sleep quality [ 29 , 30 ]. Exposure time needed to significantly suppress melatonin production may however, differ between products depending on their built-in ability to decrease brightness as well as filter out blue light [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

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The use of entertainment and communication technologies before sleep could affect sleep and weight status: a population-based study among children

Dube

Khan

Loehr

et al. 2017

Int J Behav Nutr Phys Act

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BackgroundShort sleep duration and poor sleep quality have been demonstrated to be associated with childhood obesity. It has been suggested that electronic entertainment and communication devices (EECDs) including TVs, computers, tablets, video games and cell phones interfere with sleep in children and youth. The aim of this study was to assess the impact that the use of EECDs in the hour before bedtime has on sleep and weight status to inform sleep promotion interventions and programs to prevent childhood obesity.MethodsA provincially representative sample of 2334 grade 5 children and their parents in Alberta, Canada was surveyed. Parents reported their child’s bedtime and wake-up time along with how often their child snored, felt sleepy during the day, woke-up at night and woke-up in the morning feeling unrefreshed. Sleep duration, sleep quality and sleep efficiency were derived from these indicators. Parents also reported on the presence of EECDs in their child’s bedroom, while children reported use of EECDs during the day and frequency of using each of these devices during the hour before sleep. The height and weight of children were measured. Multivariable mixed effect linear and logistic regression models were used to determine how sleep duration, sleep quality, sleep efficiency and weight status are influenced by (i) access to EECDs in children’s bedrooms, (ii) use of EECDs during the hour before sleep, and (iii) calming activities specifically reading during the hour before sleep.ResultsSleep duration was shorter by −10.8 min (cell phone), −10.2 min (computer) and −7.8 min (TV) for those with bedroom access to and used these EECDs during the hour before sleep compared to no access and no use. Good sleep quality was hindered by bedroom access to and use of all EECDs investigated during the hour before sleep, particularly among users of cell phones (OR = 0.64, 95% CI: 0.58–0.71) and computers (OR = 0.72, 95% CI: 0.65–0.80). Very good sleep efficiency was decreased by access to and frequent use of a TV (54%), cell phone (52%), tablet (51%) and video games (51%). Odds of obesity were doubled by bedroom access to and use of a TV and computer during the hour before sleep. Children who rarely read a printed book in the bedroom during the hour before sleep had a shorter sleep duration and poorer sleep quality and sleep efficiency compared to their peers. Having access to an EECD in the bedroom was associated with increased obesity despite frequently reading during the hour before sleep.ConclusionsOur findings suggest that sleep duration, sleep quality, sleep efficiency and weight status are better among children who do not have EECDs in the bedroom and frequently read a book during the hour before sleep as opposed to those who use EECDs during this hour. Education of limits against EECD use by parents may improve sleep outcomes. These findings will inform health promotion messages and may give rise to national recommendations regarding EECD use.Trial registrationClinicalTrials.gov NCT01914185. Registered 31 July ...

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

The use of entertainment and communication technologies before sleep could affect sleep and weight status: a population-based study among children

Dube

Khan

Loehr

et al. 2017

Int J Behav Nutr Phys Act

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“…Visualization and analysis of gene expression in tissue sections by spatial transcriptomics Patrik L. Ståhl, 1,2 * Fredrik Salmén, 2 * Sanja Vickovic, 2 † Anna Lundmark, 2,3 † José Fernández Navarro, 1,2 Jens Magnusson, 1 Stefania Giacomello, 2 Michaela Asp, 2 Jakub O. Westholm, 4 Mikael Huss, 4 Annelie Mollbrink, 2 Sten Linnarsson, 5 Simone Codeluppi, 5,6 Åke Borg, 7 Fredrik Pontén, 8 Paul Igor Costea, 2 Pelin Sahlén, 2 Jan Mulder, 9 Olaf Bergmann, 1 Joakim Lundeberg, 2 ‡ Jonas Frisén 1…”

Section: Transcriptionmentioning

confidence: 99%

“…After capturing and reverse-transcribing mRNA, we generated sequencing libraries based on amplification by in vitro transcription (fig. S3, A and B)(7,8). Comparison with data from RNA extracted and fragmented in solution revealed that~95% of the genes found with one of the methods was also found with the other(fig.…”

mentioning

confidence: 99%

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

Ståhl

Salmén

Vicković

et al. 2016

Science

2,326

2,155

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Analysis of the pattern of proteins or messengerRNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics. This typically involves the visualization of a few proteins or expressed genes at a time. We have devised a strategy, which we call "spatial transcriptomics," that allows visualization and quantitative analysis of the transcriptome with spatial resolution in individual tissue sections. By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, we demonstrate high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer. Spatial transcriptomics provides quantitative gene expression data and visualization of the distribution of mRNAs within tissue sections and enables novel types of bioinformatics analyses, valuable in research and diagnostics.

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“…The mechanism behind the impairment of sleep quality might be related to bright light emitted by many devices . The blue light‐rich diodes that are used as a backlight in many EECDs suppress the melatonin hormone, thus delaying sleep onset, shortening sleep duration, and lowering sleep quality . It has been shown that exposure to the light emitted by self‐luminous Apple iPad tablets for 1 h did not decrease melatonin production but when the time of exposure was increased to 2 h, melatonin production was decreased, delaying sleep onset .…”

Section: Discussionmentioning

confidence: 99%

The effect of using entertainment and communication devices before sleep on nocturnal enuresis

Döven

2020

Pediatrics International

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Background: Monosymptomatic nocturnal enuresis (MNE) is a common urological problem. The association between the use of entertainment and communication devices (EECDs) at night and enuresis in MNE patients has yet to be reported in the literature. This study aims to determine if an association exists between the use of EECDs before sleep and nocturnal enuresis. Methods: Patients with MNE who presented to the pediatric nephrology department of the center between January 30, 2019 and June 30, 2019 were included in the study. A questionnaire was administered both to the patients and to an age-and sex-matched control group to garner details of sleeping features and duration of exposure to EECDs before sleep. A comparison was then made of the answers provided by the patient and control groups. Results: The study included 138 patients (65 females; 73 males) and 104 controls (44 females; 60 males). The patients who used EECDs for more than 3 h a day before sleep suffered more frequently from bedwetting than those who used EECDs for fewer than 3 h a day (P = 0.007). The time of exposure to EECDs before sleep in the patient group was longer than in the control group (P < 0.001). Conclusions: The use of EECDs for more than 3 hours before sleep is associated with bedwetting and enuresis frequency in patients with MNE. Patients suffering from MNE should be advised not to use EECDs before sleep.

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A tablet that shifts the clock

Cited by 4 publications

References 19 publications

The use of entertainment and communication technologies before sleep could affect sleep and weight status: a population-based study among children

The use of entertainment and communication technologies before sleep could affect sleep and weight status: a population-based study among children

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

The effect of using entertainment and communication devices before sleep on nocturnal enuresis

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