A T Cell View of the Bone Marrow

Bonomo, Adriana; Monteiro, Ana Carolina; Gonçalves-Silva, Triciana; Cordeiro-Spinetti, Eric; Galvani, Rômulo Gonçalves; Balduino, Alex

doi:10.3389/fimmu.2016.00184

Cited by 39 publications

(29 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of endosteal cells and their distance from the surface of the bone is the focus of research of the group of Balduino. Thus, the bone marrow also has a 3D structure with defined special differences . The role of adhesion molecules and their regulation in the recruitment of CD8 + memory T cells was studied by sophisticated in vivo techniques in mice, confirming that the bone marrow is a major reservoir and site of recruitment for central memory CD8 + T cells .…”

Section: Introductionmentioning

confidence: 91%

The bone marrow is not only a primary lymphoid organ: The critical role for T lymphocyte migration and housing of long‐term memory plasma cells

Pabst

2018

Eur J Immunol

View full text Add to dashboard Cite

In immunology and anatomy textbooks the bone marrow is described as a typical "primary lymphoid organ" producing lymphoid cells independent of antigens. The hematopoietic bone marrow is largely age-dependent organ with great anatomical and functional differences among various species. There are estimates that about 12% of all lymphoid cells in the human body are found in the bone marrow at any given time (2% in the peripheral blood). Enormous numbers of T lymphocytes migrate to the bone marrow and partly return later to the blood. Many of these lymphocytes are memory CD4 and CD8 T cells. A few days after immunization a wave of plasma cells and their precursors migrate to the bone marrow where they lose their migratory response to CXCL-12 and CXCL9. There is a relative enrichment of CD19 B cells in the bone marrow outnumbering those in the blood and secondary lymphoid organs. This is not due to local production. The proliferation and migration kinetics of these lymphoid cells in the bone marrow have to be studied in more detail as this is of major clinical relevance.

show abstract

Section: Introductionmentioning

confidence: 91%

The bone marrow is not only a primary lymphoid organ: The critical role for T lymphocyte migration and housing of long‐term memory plasma cells

Pabst

2018

Eur J Immunol

View full text Add to dashboard Cite

show abstract

“…The role of BM in the maintenance of antigen-experienced adaptive immune cells is well documented as reviewed in [41]. Moreover, immune response is altered in patients with T2D, with the most apparent cellular changes occurring in adipose tissue, pancreatic islets, and vasculature [9].…”

Section: Discussionmentioning

confidence: 99%

Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept

Santopaolo

Sullivan²,

Thomas

et al. 2020

Preprint

View full text Add to dashboard Cite

AbstractHypothesisType 2 diabetes (T2D) is characterized by low-grade inflammation. Here, we investigated the state of adaptive immunity in bone marrow (BM) of patients and mice with T2D. We also tested if inhibition T cell co-stimulation by Abatacept could rescue the immune profile of T2D mice.MethodsFlow-cytometry and cytokine analyses were performed on BM samples from patients with or without T2D. Moreover, we studied the immune profile of db/db and control wt/db mice. A cohort of db/db mice was randomized to receive Abatacept or vehicle for 4 weeks, with endpoints being immune cell profile and indexes of insulin sensitivity and heart performance.ResultsT2D patients showed increased frequencies of BM CD4+ (2.8-fold, p=0.001) and CD8+ T cells (1.8-fold, p=0.01), with upregulation of the activation marker CD69 and homing receptor CCR7 in CD4+ (1.64-fold, p=0.003 and 2.27-fold, p=0.01, respectively) and CD8+ fractions (1.79-fold, p=0.05 and 1.69-fold, p=0.02, respectively). CCL19 (CCR7 receptor ligand) and CXCL10/11 (CXCR3 receptor ligands), implicated in T cell migration and activation, were the most differentially modulated chemokines. Studies in mice confirmed the activation of adaptive immunity in T2D. Abatacept reduced the activation of T cells and levels of pro-inflammatory chemokines and cytokines. Additionally, Abatacept improved indexes of cardiac systolic function, but not insulin sensitivity.ConclusionsThese novel findings support the concept of BM adaptive immune activation in T2D. Modulation of T cell co-stimulation could represent an attractive and immediately available modality to dampen inappropriate activation of adaptive immune response and protect from target organ damage.

show abstract

“…The BM cavity in the trabecular bone is subdivided into four regions: endosteal, sub-endosteal, central, and perisinusoidal regions [12]. In Figure 1, the four regions, according to the model of Lambertsen and Weis, have been adopted and modified [13].…”

Section: Bone Marrow-specific Regionsmentioning

confidence: 99%

The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use in Regenerative Medicine Applications

Everts¹,

Flanagan²,

Rothenberg³

et al. 2020

Regenerative Medicine

View full text Add to dashboard Cite

Autologously prepared bone marrow aspirate concentrates, have the potential to play an adjunctive role in various patient pathologies that have not been able to heal with conventional treatment modalities. The use of bone marrow aspirate (BMA) and concentrates in regenerative medicine treatment plans and clinical applications is based on the fact that bone marrow cells, including progenitor and nucleated cells, platelets, and other cytokines, support in tissue healing and tissue regenerative processes. The use of concentrated BMA cells focuses primarily on mesenchymal stem cells (MSCs), with the ability to self-renew and differentiate into multiple cell types. Concentrated bone marrow cells can be retrieved from harvested BMA and ensuing minimal manipulative cell processing techniques, executed at point of care (POC). The application of bone marrow biological therapies may offer solutions in musculoskeletal pathologies, spinal disorders, chronic wound care, and critical limb ischemia (CLI), to effectively change the local microenvironment to support in tissue healing and facilitate tissue regeneration. This chapter will address the cellular content of bone marrow tissue, harvesting and preparation techniques, and discuss the biological characteristics of individual marrow cells, their inter-connectivity, and deliberate on the effects of BMA concentration.

show abstract

A T Cell View of the Bone Marrow

Cited by 39 publications

References 158 publications

The bone marrow is not only a primary lymphoid organ: The critical role for T lymphocyte migration and housing of long‐term memory plasma cells

The bone marrow is not only a primary lymphoid organ: The critical role for T lymphocyte migration and housing of long‐term memory plasma cells

Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept

The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use in Regenerative Medicine Applications

Contact Info

Product

Resources

About