A Systems Biology View of Drug Transporters

Computational Modeling to Accelerate the Identification of Substrates and Inhibitors for Transporters That Affect Drug Disposition

“…Consequently, increasing attention is being paid to the potential for transport-based toxicity in vivo , and to unwanted drug-drug interactions [6–9] and consequences from polymorphic transport activity [10]. Furthermore, with hundreds of transporters yet to be characterized, the potential exists for many new drug targets to be discovered [8].…”