2014
DOI: 10.1093/toxsci/kfu094
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A Systems Biology Approach Utilizing a Mouse Diversity Panel Identifies Genetic Differences Influencing Isoniazid-Induced Microvesicular Steatosis

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Cited by 50 publications
(36 citation statements)
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“…Fatty acyl-CoAs are intermediates in fatty acid β-oxidation [37]. The formation of INH-fatty acid amides indicates that INH can disturb fatty acid β-oxidation, which can therefore contribute to INH-induced microvesicular steatosis and INH hepatotoxicity [17, 38, 39]. In the current study, we observed higher levels of INH-fatty acid amides in the liver of Nat1/2(−/−) mice than WT mice, suggesting that deficiency of NAT1/2 promotes INH-mediated disruption of fatty acid metabolism in the liver and potentiates INH-induced fatty liver.…”
Section: Discussionmentioning
confidence: 99%
“…Fatty acyl-CoAs are intermediates in fatty acid β-oxidation [37]. The formation of INH-fatty acid amides indicates that INH can disturb fatty acid β-oxidation, which can therefore contribute to INH-induced microvesicular steatosis and INH hepatotoxicity [17, 38, 39]. In the current study, we observed higher levels of INH-fatty acid amides in the liver of Nat1/2(−/−) mice than WT mice, suggesting that deficiency of NAT1/2 promotes INH-mediated disruption of fatty acid metabolism in the liver and potentiates INH-induced fatty liver.…”
Section: Discussionmentioning
confidence: 99%
“…4551 Free induction decays (FIDs) were zero-filled to 64k and a line broadening factor of 0.5 Hz was applied before Fourier transformation. Spectra were manually phased, baseline corrected, and referenced to DSS.…”
Section: Methodsmentioning
confidence: 99%
“…Analysis of NMR spectra was conducted as previously described (Church, et al 2014, Pathmasiri, et al 2012, Sumner, et al 2009, Sumner, et al 2010a, Sumner, et al 2015, Sumner, et al 2010b). Briefly, NMR data were processed by automated integration (increments of 0.04 ppm) over the spectral window (binning), excluding the region of water suppression, and DSS signal, and intensities each of the bins was normalized to the total integral of the bins of each spectrum.…”
Section: Methodsmentioning
confidence: 99%