A systems biology approach to identify the key targets of curcumin and capsaicin that downregulate pro-inflammatory pathways in human monocytes

Shekarappa, Sharath Belenahalli; Kandagalla, Shivananda; Malojirao, Vikas H.; G.S, Pavan Kumar; B.T, Prabhakar; Hanumanthappa, M.

doi:10.1016/j.compbiolchem.2019.107162

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…In this study, the addition of CAP increased the concentration of three immunoglobulins (IgA, IgG and IgM) as well as IL-10, while reducing serum concentration of IL-1β and IL-6, with the high dose of CAP showing better effects. Similar studies have found that CAP may downregulate the expression of pro-inflammatory cytokines, such as TNF-α, IL-6 and IL-8, through the NF-κB signaling pathway, while upregulating the expression of the anti-inflammatory cytokine IL-10 [ 29 , 30 ]. CAP has been shown to enhance the immune capacity of rats by increasing IL-10 concentration and suppressing the expression of IL-6 cytokines [ 9 ].…”

Section: Discussionmentioning

confidence: 82%

Effect of Capsaicin Addition on Antioxidant Capacity, Immune Performance and Upper Respiratory Microbiota in Nursing Calves

She

Deng

et al. 2023

Microorganisms

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Capsaicin (CAP) has various biological activities; it has antibacterial, anti-inflammatory and antioxidant properties, and stimulates intestinal development. The aim of this study was to investigate the effect of CAP on the health of nursing calves under group housing conditions. Twenty-four newborn Holstein calves were randomly assigned to three treatment groups of eight calves each. The milk replacer was supplemented with 0, 0.15 or 0.3 mL/d of CAP in each of the three treatment groups. Following a one-month clinical trial of individual-pen housing, an extended one-month trial of group housing was conducted. At the end of the trial, serum samples, rectal fecal samples and upper respiratory swab samples were collected to determine the effect of CAP addition on serum parameters, fecal fermentation parameters and upper respiratory microbiota of calves under group housing conditions. The results showed that the addition of high doses of CAP decreased calf respiratory scores (p < 0.05), increased serum glutathione peroxidase, superoxide dismutase, immunoglobulin A, immunoglobulin G, immunoglobulin M and interleukin-10 concentration (p < 0.05), and decreased malondialdehyde, amyloid A and haptoglobin concentration (p < 0.05). Moreover, high doses of CAP increased the rectal fecal concentration of total short-chain fatty acids, acetate and butyric acid (p < 0.05). In addition, CAP regulated the upper respiratory tract microbiota, with high doses of CAP reducing Mycoplasma abundance (p < 0.05), two doses of CAP reducing Corynebacterium abundance (p < 0.05) and a tendency to reduce Staphylococcus abundance (p = 0.06). Thus, CAP can improve calf antioxidant capacity, immune capacity and reduce inflammatory factors, stress proteins as well as improve gut fermentation and upper respiratory microbiota under group housing conditions, which is beneficial for healthy calf growth.

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Section: Discussionmentioning

confidence: 82%

Effect of Capsaicin Addition on Antioxidant Capacity, Immune Performance and Upper Respiratory Microbiota in Nursing Calves

She

Deng

et al. 2023

Microorganisms

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“…Capsaicin (CAP; also known as 8-methyl-N-vanillyltrans-6-nonenamide) is one of the naturally pungent components of chili peppers, which are varieties of plants from the genus Capsicum (16). CAP is known to affect inflammation through a variety of different pathways, such as the anti-inflammatory response and nociception pathways (17)(18)(19)(20)(21)(22)(23), and while CAP may potentially promote wound healing, little is known regarding the mechanism of this process (24). In the present study, the effects of CAP on wound healing were analyzed using both an in vitro cell model and an in vivo animal model.…”

Section: Improvement Of Wound Healing By Capsaicin Through Suppressio...mentioning

confidence: 99%

Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process

Huang,

Pu,

et al. 2023

Mol Med Rep

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Wound healing is a complex biological process involving cytokines with four phases: Hemostasis, inflammation, proliferation and remodeling. Understanding the molecular mechanism of the inflammation phase could improve wound healing in the clinic as excess inflammation is a critical point for dysregulation of normal wound healing. Capsaicin (CAP), a major component of chili peppers, is known to exhibit anti-inflammatory properties through a range of different pathways, such as the neurogenic inflammation and nociception pathways. To improve the understanding of the relationship between CAP and wound healing, it is crucial to elucidate the CAP-related molecular panel involved in regulating inflammation. Therefore, the present study aimed to analyze the effects of CAP on wound healing using an in vitro cell model and an in vivo animal model. Cell migration, viability and inflammation were examined using fibroblasts, and wounds were evaluated in mice under CAP treatment. In the present study, it was found that 10 µM CAP increased cell migration and decreased interleukin 6 (IL-6) expression in in vitro cell assays. In the in vivo animal experiments, the CAP-treated wounds exhibited lower densities of polymorphonuclear neutrophils and monocytes/macrophages, as well as lower IL-6 and C-X-C motif chemokine ligand 10 protein levels. Furthermore, in CAP-treated wounds, CD31-positive capillaries and collagen deposition at the late phase of wound healing were present at higher densities. In summary, an improvement in wound healing by CAP was shown through suppression of the inflammatory response and amelioration of the repair process. These findings suggest that CAP has potential as a natural therapeutic agent for the treatment of wound healing.

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A systems biology investigation of curcumin potency against TGF-β-induced EMT signaling in lung cancer

et al. 2022

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A systems biology approach to identify the key targets of curcumin and capsaicin that downregulate pro-inflammatory pathways in human monocytes

Cited by 4 publications

References 49 publications

Effect of Capsaicin Addition on Antioxidant Capacity, Immune Performance and Upper Respiratory Microbiota in Nursing Calves

Effect of Capsaicin Addition on Antioxidant Capacity, Immune Performance and Upper Respiratory Microbiota in Nursing Calves

Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process

A systems biology investigation of curcumin potency against TGF-β-induced EMT signaling in lung cancer

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