A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer

Scott, Nancy; Whittle, Emma; Jeraldo, Patricio; Chia, Nicholas

doi:10.1016/j.neo.2022.100797

Cited by 22 publications

(15 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, studies have proven that the extracellular polysaccharide produced by Lactobacillus can effectively inhibit the proliferation of colon cancer cells in vitro ( 51 ). High concentrations of enterotoxigenic Bacteroides fragilis in the genus Bacteroidetes are closely associated with colorectal cancer ( 52 ). We believe that the changes in these two intestinal microflora may be an important link for THP to exert its antitumor effects.…”

Section: Discussionmentioning

confidence: 99%

Antitumor effects of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via regulation of intestinal flora and enhancing immunomodulatory effects in vivo

Zhou

Sun

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Tetrastigma hemsleyanum Diels et Gilg is a traditional Chinese herbal medicine with high medicinal value, and antitumor, antioxidant and anti-inflammatory biological activities. However, while several studies have focused on flavonoids in Tetrastigma hemsleyanum tubers, there are few studies on the enhanced immune effect of Tetrastigma hemsleyanum polysaccharides (THP). In this study, we evaluated the antitumor effect of THP in a lung tumor model and explored the mechanism of antitumor activity through intestinal flora. In addition, a cyclophosphamide (CTX)-induced immunosuppression model was used to declare the immunomodulatory effect of THP in the immunosuppressive state induced by antitumor drugs. The results showed that THP increased the content of ileum secreted immunoglobulin A (SIgA) and cecum short-chain fatty acids (SCFAs) and improved microbial community diversity, regulating the relative abundance of dominant microbiota flora from the phylum level to the genus level, and recovering the intestinal microflora disorder caused by tumors. Additionally, THP can increase the organ indices and improve immune organ atrophy. THP can upregulate routine blood counts and stimulate the production of the serum cytokines. THP also promoted the macrophage phagocytic index, NK-cell activation, and complement and immunoglobulin (IgG, IgA, IgM) levels. The detection of Splenic lymphocyte proliferation and T lymphocyte subsets also sideways reflects that THP can restore CTX-induced immune inhibition in mice. In conclusion, this study suggests that THP can effectively achieve the enhanced antitumor effects, regulate gut microbiota and improve the immunosuppression induced by antitumor drugs. Therefore, THP can enhance the immune capacity and provide novel immunomodulatory and antineoplastic adjuvant agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Antitumor effects of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via regulation of intestinal flora and enhancing immunomodulatory effects in vivo

Zhou

Sun

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In twenty-six studies carried out where mice were either given enterotoxigenic Bacteroides fragilis toxin or non-toxigenic Bacteroides fragilis (NTBF), 24 out the 26 revealed pathogenic induced traits that were linked with CRC, and the 26 studies that colonized mice with enterotoxigenic Bacteroides fragilis toxin and nontoxigenic Bacteriodes fragilis, comprised tumor formation in 11 of the studies; other findings notes included gut mucosal inflammation shown in six studies, polyp formation in two studies, colitis in six studies; other findings reported were ulcers, splenic enlargement, and macroadenoma [15]. Amongst the Bacteroides spp, there was a notable rise in the amount of Bacteroides massileinses and Bacteroides dorei from healthy patients to patients with colonic adenoma.…”

Section: Bacteroides Speciesmentioning

confidence: 99%

“…2022 [15] SANRA [12] Narrative Review Six items: justification of the article's importance to the readership, statement of concrete aims or formulation of questions, description of the literature search, referencing, scientific reason, and appropriate presentation of data. Scored as 0, 1 or 2.…”

mentioning

confidence: 99%

Microbiota Dysbiosis a Cause of Colorectal Cancer or Not? A Systematic Review

Tabowei¹,

Gaddipati²,

Mukhtar³

et al. 2022

Cureus

View full text Add to dashboard Cite

Deaths from colorectal cancer (CRC) are still rising, and various links to etiology have been proposed. However, a direct link between microbial dysbiosis and colorectal cancer has not been postulated. This study aimed to identify the role of microbes in the pathogenesis of colorectal cancer. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was done considering papers published over the past 12 years, using PubMed, PubMed Central, Cochrane, Google Scholar, and ScienceDirect databases. Studies were selected based on the following predefined eligibility criteria: English-language systematic reviews, meta-analysis, randomized controlled trials (RCTs), and clinical trials, which included papers on microbes playing roles in colorectal cancer with the derived data transferred to a template. Following this, quality assessment was done using each study's relevant assessment tool. The initial search generated 128 studies. From the study, we found the ratio of Fusobacterium, when compared between healthy and colorectal cancer patients' guts, was the highest, although it was not the most predominant gut organism. Enterotoxigenic Bacteroides fragilis (ETBF), Clostridium and Salmonella, and Peptostreptococcus showed links with colorectal cancer and described pathways that could explain its implication in colorectal cancer. However, overt conclusions cannot be drawn because further research needs to be conducted.Categories: Internal Medicine, Gastroenterology Keywords: microbes or ("microbiota" [all fields] or "microbiome" [all fields]) and ("colorectal cancer" [all fields] or "colorectal carcinogenesis" [all fields] or "colon cancer" [all fields] or "rectal cancer" [all fields]), microbes associated with crc, colerectal carcinogenesis, microbial dysbiosis, microbes and colorectal cancer

show abstract

“…Remarkable progress has been achieved in studies relating to gut microbiota and CRC, highlighting the distinguished value of diagnosis and therapeutic prediction of the gut microbiome (6,7). Bacterial strains such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis are known for their tumor activities (8)(9)(10). However, there are many uncertainties concerning the association between gut microbiome and CRC, such as the huge number of bacteria (approximately 100 million) and distinct microbiota signatures, bacterial interactions, as well as geographical and race differences (11).…”

Section: Introductionmentioning

confidence: 99%

Investigation of trends in gut microbiome associated with colorectal cancer using machine learning

Zhou²,

Liu³

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundThe rapid growth of publications on the gut microbiome and colorectal cancer (CRC) makes it feasible for text mining and bibliometric analysis.MethodsPublications were retrieved from the Web of Science. Bioinformatics analysis was performed, and a machine learning-based Latent Dirichlet Allocation (LDA) model was used to identify the subfield research topics.ResultsA total of 5,696 publications related to the gut microbiome and CRC were retrieved from the Web of Science Core Collection from 2000 to 2022. China and the USA were the most productive countries. The top 25 references, institutions, and authors with the strongest citation bursts were identified. Abstracts from all 5,696 publications were extracted for a text mining analysis that identified the top 50 topics in this field with increasing interest. The colitis animal model, expression of cytokines, microbiome sequencing and 16s, microbiome composition and dysbiosis, and cell growth inhibition were increasingly noticed during the last two years. The 50 most intensively investigated topics were identified and further categorized into four clusters, including “microbiome sequencing and tumor,” “microbiome compositions, interactions, and treatment,” “microbiome molecular features and mechanisms,” and “microbiome and metabolism.”ConclusionThis bibliometric analysis explores the historical research tendencies in the gut microbiome and CRC and identifies specific topics of increasing interest. The developmental trajectory, along with the noticeable research topics characterized by this analysis, will contribute to the future direction of research in CRC and its clinical translation.

show abstract

A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer

Cited by 22 publications

References 118 publications

Antitumor effects of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via regulation of intestinal flora and enhancing immunomodulatory effects in vivo

Antitumor effects of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via regulation of intestinal flora and enhancing immunomodulatory effects in vivo

Microbiota Dysbiosis a Cause of Colorectal Cancer or Not? A Systematic Review

Investigation of trends in gut microbiome associated with colorectal cancer using machine learning

Contact Info

Product

Resources

About