A systematized and chemometrics‐assisted liquid chromatography coupled with tandem mass spectrometry method for quantification of aripiprazole in implantable microparticles in rat plasma from pharmacokinetic study

Rub, Rehan Abdur; Panda, Sagar Suman; Panda, Santosh Kumar; Almalki, Waleed Hassan; Alrobaian, Majed; Hafeez, Abdul; Rahman, Mahfoozur; Beg, Sarwar; Ali, Asgar; Ahmed, Farhan

doi:10.1002/sscp.202200053

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…For example, the National Environmental Methods Index (NEMI) is a qualitative approach used by a few researchers to identify the potential green nature of an analytical procedure [17,18]. However, to complement it and confirm the method greenness semiquantitative approach of Analytical Eco-Scale (AES) can be incorporated [19][20][21][22]. The overall goal of such assessment tools is to present the sustainable green nature of the analytical methods and safeguard the environment over time while not compromising method performance.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatographic methods for simultaneous quantification of fixed‐dose combinations of pantoprazole with itopride and ondansetron: Application to method greenness assessment

Panda

Panigrahi

Mohanty

et al. 2023

Separation Science Plus

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Two liquid chromatography methods are developed to quantify pantoprazole and its fixed-dose counterparts, itopride hydrochloride, and ondansetron. The basic chromatography utilized a C-18 column (150 × 4.6 mm × 5 μm) with a simple mobile phase of methanol: 0.01 M potassium dihydrogen phosphate buffer of pH 3.5 (80:20 v/v) with a flow rate of 1.0 ml/min. The diode array detections were performed at 273 nm (Method-I) and 280 nm (Method-II). The validation of parameters like linearity (R 2 > 0.99), accuracy (98%-103%), precision (≤1 %), system suitability, and so forth, was found satisfactory for both methods. A risk estimation approach helped sort out method variables methanol%, pH, and flow rate and highlighted their influence on the method's robustness. The developed methods aptly quantified all the target analytes with the maximum possible recovery from combined pharmaceuticals. Assessment of the method greenness profile revealed excellent method greenness with maximal green shades in a pictogram and a greenness score of 89. The developed analytical methods are green and befitting for routine quality control of two widely used fixed-dose combinations of pantoprazole.

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Section: Introductionmentioning

confidence: 99%

Liquid chromatographic methods for simultaneous quantification of fixed‐dose combinations of pantoprazole with itopride and ondansetron: Application to method greenness assessment

Panda

Panigrahi

Mohanty

et al. 2023

Separation Science Plus

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Spectrofluorometric quantitative analysis of aripiprazole based on quenching of natural derived carbon quantum dots in spiked human plasma

Alaqel,

Alqahtani,

Alharbi

et al. 2023

Sci Rep

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Autism spectrum disorder is a significant concern worldwide, particularly in Middle Eastern countries. Aripiprazole, a psychiatric medicine that works as a partial agonist at D2 receptors, is often used for autism-related behavior issues in children. Monitoring the therapy of aripiprazole could enhance the safety and effectiveness of treatment for autistic individuals. The purpose of this study was to develop a highly sensitive and environmentally friendly method for analysis of aripiprazole in plasma matrix. To achieve this, water-soluble N-carbon quantum dots were produced from a natural green precursor, guava fruit, and used in fluorescence quenching spectroscopy to determine the presence of aripiprazole. The synthesized dots were analyzed and characterized using transmission electron microscopy and Fourier transform infrared spectroscopy, and they showed a strong fluorescence emission peak at 475 nm. The proposed method was validated according to ICH M10 guidelines and was shown to be highly sensitive, allowing for nanoscale determination of aripiprazole in plasma matrix. Additionally, the method was compared to a previously reported spectrophotometric method, and it was found to be more sensitive and consistent with the principles of green analytical chemistry.

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A systematized and chemometrics‐assisted liquid chromatography coupled with tandem mass spectrometry method for quantification of aripiprazole in implantable microparticles in rat plasma from pharmacokinetic study

Abstract: A systematized and chemometrics-assisted liquid chromatography coupled with tandem mass spectrometry method for quantification of aripiprazole in implantable microparticles in rat plasma from pharmacokinetic study.

Cited by 2 publications

References 26 publications

Liquid chromatographic methods for simultaneous quantification of fixed‐dose combinations of pantoprazole with itopride and ondansetron: Application to method greenness assessment

Liquid chromatographic methods for simultaneous quantification of fixed‐dose combinations of pantoprazole with itopride and ondansetron: Application to method greenness assessment

Spectrofluorometric quantitative analysis of aripiprazole based on quenching of natural derived carbon quantum dots in spiked human plasma

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