A systematical review on antimicrobial peptides and their food applications

Xu, Kangjie; Zhao, XinYi; Tan, Yameng; Wu, Junheng; Cai, Yiqing; Zhou, Jingwen; Wang, Xinglong

doi:10.1016/j.bioadv.2023.213684

Cited by 5 publications

(5 citation statements)

References 130 publications

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“…Moreover, active packaging is used to carry AMPs in microcapsules and nano-capsules, controlling the release of AMPs to combat microbes during food preservation. However, not all types of AMPs can act as potential ingredients in packaging-this depends on their effectiveness [170,171]. There is a growing demand for food supply as the population increases.…”

Section: Potential Applications Of Insect Ampsmentioning

confidence: 99%

Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review

Zhou,

Meng,

Zhu

et al. 2024

IJMS

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Antimicrobial peptides (AMPs), as immune effectors synthesized by a variety of organisms, not only constitute a robust defense mechanism against a broad spectrum of pathogens in the host but also show promising applications as effective antimicrobial agents. Notably, insects are significant reservoirs of natural AMPs. However, the complex array of variations in types, quantities, antimicrobial activities, and production pathways of AMPs, as well as evolution of AMPs across insect species, presents a significant challenge for immunity system understanding and AMP applications. This review covers insect AMP discoveries, classification, common properties, and mechanisms of action. Additionally, the types, quantities, and activities of immune-related AMPs in each model insect are also summarized. We conducted the first comprehensive investigation into the diversity, distribution, and evolution of 20 types of AMPs in model insects, employing phylogenetic analysis to describe their evolutionary relationships and shed light on conserved and distinctive AMP families. Furthermore, we summarize the regulatory pathways of AMP production through classical signaling pathways and additional pathways associated with Nitric Oxide, insulin-like signaling, and hormones. This review advances our understanding of AMPs as guardians in insect immunity systems and unlocks a gateway to insect AMP resources, facilitating the use of AMPs to address food safety concerns.

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Section: Potential Applications Of Insect Ampsmentioning

confidence: 99%

Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review

Zhou,

Meng,

Zhu

et al. 2024

IJMS

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“…It offers strong stability, high solubility, and a small molecular weight and exhibits resistance to drug resistance. 13 Hence, their applicability in the field of medicine holds great promise.…”

Section: Introductionmentioning

confidence: 99%

“…The strong antimicrobial properties of these substances have been observed against a diverse range of microorganisms, encompassing bacteria, fungi, and viruses. − It possesses strong stability, high solubility, and low molecular weight, and resistance to drug development is not likely. It offers strong stability, high solubility, and a small molecular weight and exhibits resistance to drug resistance . Hence, their applicability in the field of medicine holds great promise.…”

Section: Introductionmentioning

confidence: 99%

Screening of Short-Chain Antimicrobial Peptide LKARI with Broad-Spectrum Bactericidal Properties and Its Application in Promoting Wound Healing

Wu,

Wang,

Ren

et al. 2024

ACS Appl. Mater. Interfaces

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“…Antimicrobial peptides (AMPs) constitute a class of small-molecule peptides that are widely present in nature, and which typically comprise fewer than 100 amino acids. They aid the body in defending against external microorganisms and constitute an integral component of the innate immune system [ 1 ]. It is generally believed that AMPs primarily disrupt the integrity of microorganism cell membranes or cell walls to inhibit or kill microorganisms.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Pipeline and Overexpression of a Novel Efflux Transporter, YoeA, Significantly Increases Plipastatin Production in Bacillus subtilis

Wang,

Zheng,

Sun

et al. 2024

Foods

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Plipastatin, an antimicrobial peptide produced by Bacillus subtilis, exhibits remarkable antimicrobial activity against a diverse range of pathogenic bacteria and fungi. However, the practical application of plipastatin has been significantly hampered by its low yield in wild Bacillus species. Here, the native promoters of both the plipastatin operon and the sfp gene in the mono-producing strain M-24 were replaced by the constitutive promoter P43, resulting in plipastatin titers being increased by 27% (607 mg/mL) and 50% (717 mg/mL), respectively. Overexpression of long chain fatty acid coenzyme A ligase (LCFA) increased the yield of plipastatin by 105% (980 mg/mL). A new efflux transporter, YoeA, was identified as a MATE (multidrug and toxic compound extrusion) family member, overexpression of yoeA enhanced plipastatin production to 1233 mg/mL, an increase of 157%, and knockout of yoeA decreased plipastatin production by 70%; in contrast, overexpression or knockout of yoeA in mono-producing surfactin and iturin engineered strains only slightly affected their production, demonstrating that YoeA acts as the major exporter for plipastatin. Co-overexpression of lcfA and yoeA improved plipastatin production to 1890 mg/mL, which was further elevated to 2060 mg/mL after abrB gene deletion. Lastly, the use of optimized culture medium achieved 2514 mg/mL plipastatin production, which was 5.26-fold higher than that of the initial strain. These results suggest that multiple strain engineering is an effective strategy for increasing lipopeptide production, and identification of the novel transport efflux protein YoeA provides new insights into the regulation and industrial application of plipastatin.

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A systematical review on antimicrobial peptides and their food applications

Cited by 5 publications

References 130 publications

Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review

Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review

Screening of Short-Chain Antimicrobial Peptide LKARI with Broad-Spectrum Bactericidal Properties and Its Application in Promoting Wound Healing

An Integrated Pipeline and Overexpression of a Novel Efflux Transporter, YoeA, Significantly Increases Plipastatin Production in Bacillus subtilis

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