A Systematic Review on the Association between Rhinovirus and Sinusitis

Abstract

RATIONALE: Aspirin exacerbated respiratory disease (AERD) is a challenging upper and lower respiratory disease which requires joint management between allergists and otolaryngologists. Complete sinus surgery followed by aspirin desensitization (AD) appears to improve outcomes long-term. Recent studies have demonstrated a relationship between high preoperative, pre-AD sinonasal symptoms scores and severity of reactions during AD. In this study, we provide the first evidence for using stratified preoperative, pre-AD sinonasal symptom scores to predict postoperative, post-AD outcomes. METHODS: Retrospective chart review of all patients with aspirin challenge-proven AERD who underwent complete endoscopic sinus surgery followed by AD. Preoperative, postoperative/pre-AD, and short-(<2 months) and long-term (>6 months) postoperative/post-AD sinonasal symptom scores were collected (22-item Sino-Nasal Outcomes Test, . A longitudinal linear mixed-effects model was used for data analysis. RESULTS: Preoperative SNOT-22 scores (n547) were divided into tertiles (cutoffs of 36 and 54 indicating mild [22.5613.7], moderate [44.3612.2], and severe [72.9619.7] disease). Postoperative, pre-AD SNOT-22 in all disease groups decreased and were not significantly different (12.3613.7, 11.1612.2, and 22.7619.7; p50.074). Following AD, only the severe group scores worsened (35.0620.3, p<0. Abstracts AB61 SATURDAY