A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research

Yadav, Vaishali; Krishnan, Anuja; Vohora, Divya

doi:10.1016/j.jep.2019.112255

Cited by 111 publications

(53 citation statements)

References 130 publications

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“…It possesses a variety of pharmacological activities which include diuretic, choleretic, hepatoprotective, nephroprotective, antibacterial, antiviral, anti-inflammatory, antiasthmatic, antiarrhythmic, antiobesity, cardioprotective and anticancer [61,62,63,64,65,66,67]. In the treatment of cancer matrine is used in high doses, but it has not shown any major effects on normal cells viability [61,62,63,64,65,66,67,68,69,70,71]. G1 cell cycle arrests mediation and apoptosis is the mechanism, by which matrine exerts its inhibition effects on the proliferation of different cancer cells [68,69,71,72,73].…”

Section: Natural Alkaloid Used As Anticancer Agentsmentioning

confidence: 99%

“…Piperine ( 4 in Figure 1) is a piperidine alkaloid found in Piper nigrum and Piper longum [80]. It exhibits antioxidant, antidiarrheal, anti-inflammatory, anticonvulsant, anticancer and antihyperlipidemic properties in addition to being a trigger for bile secretion production [65,81] and suppressant to the CNS system [82,83]. An administration of 50 mg/kg or 100 mg/kg of piperine daily for a week significantly reduced the size of solid tumor in mice transplanted with sarcoma 180 cells.…”

Section: Natural Alkaloid Used As Anticancer Agentsmentioning

confidence: 99%

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The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens

Thawabteh

Juma

Bader

et al. 2019

Toxins

192

101

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The growing incidence of microorganisms that resist antimicrobials is a constant concern for the scientific community, while the development of new antimicrobials from new chemical entities has become more and more expensive, time-consuming, and exacerbated by emerging drug-resistant strains. In this regard, many scientists are conducting research on plants aiming to discover possible antimicrobial compounds. The secondary metabolites contained in plants are a source of chemical entities having pharmacological activities and intended to be used for the treatment of different diseases. These chemical entities have the potential to be used as an effective antioxidant, antimutagenic, anticarcinogenic and antimicrobial agents. Among these pharmacologically active entities are the alkaloids which are classified into a number of classes, including pyrrolizidines, pyrrolidines, quinolizidines, indoles, tropanes, piperidines, purines, imidazoles, and isoquinolines. Alkaloids that have antioxidant properties are capable of preventing a variety of degenerative diseases through capturing free radicals, or through binding to catalysts involved indifferent oxidation processes occurring within the human body. Furthermore, these entities are capable of inhibiting the activity of bacteria, fungi, protozoan and etc. The unique properties of these secondary metabolites are the main reason for their utilization by the pharmaceutical companies for the treatment of different diseases. Generally, these alkaloids are extracted from plants, animals and fungi. Penicillin is the most famous natural drug discovery deriving from fungus. Similarly, marines have been used as a source for thousands of bioactive marine natural products. In this review, we cover the medical use of natural alkaloids isolated from a variety of plants and utilized by humans as antibacterial, antiviral, antifungal and anticancer agents. An example for such alkaloids is berberine, an isoquinoline alkaloid, found in roots and stem-bark of Berberis asculin P. Renault plant and used to kill a variety of microorganisms.

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Section: Natural Alkaloid Used As Anticancer Agentsmentioning

confidence: 99%

Section: Natural Alkaloid Used As Anticancer Agentsmentioning

confidence: 99%

The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens

Thawabteh

Juma

Bader

et al. 2019

Toxins

192

101

View full text Add to dashboard Cite

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“…P. longum (Piperaceae, long pepper) is cultivated almost all over India and is known to possess antimicrobial activities [14] , [15] . It is an active ingredient of Kabasura Kudineer, a traditional siddha formulation with non-toxic, drug-like properties and enhanced bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, optimization and characterization of silver nanoparticles using the catkin extract of Piper longum for bactericidal effect against food-borne pathogens via conventional and mathematical approaches

Huang

Shan

Liu

et al. 2020

Bioorganic Chemistry

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“…Piperine (1, Figure 1) is a well-known natural product that is derived from peppercorns [1][2][3]. Many biological studies of 1 have been carried out, and these studies have led to a diverse array of biological activities being claimed for this compound [4][5][6][7][8][9]. For example, 1 is reported to exhibit inhibitory activity towards both acetylcholinesterase (AChE) and β-secretase (BACE-1), which suggests that 1 could hold promise as a dual mechanism-of-action treatment for Alzheimer's disease [4,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity

Lizarme-Salas

Ariawan

Ratnayake

et al. 2020

Beilstein J. Org. Chem.

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Piperine, a natural product derived from peppercorns, has a variety of biological activities that make it an attractive lead compound for medicinal chemistry. However, piperine has some problematic physicochemical properties including poor aqueous solubility and a susceptibility to UV-induced degradation. In this work, we designed an analog of piperine in which the central conjugated hydrocarbon chain is replaced with a vicinal difluoroalkane moiety. We show that this fluorinated analog of piperine has superior physicochemical properties, and it also has higher potency and selectivity towards one particular drug target, acetylcholinesterase. This work highlights the potential usefulness of the threo-difluoroalkane motif as a surrogate for E-alkenes in medicinal chemistry.

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A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research

Cited by 111 publications

References 130 publications

The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens

The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens

Synthesis, optimization and characterization of silver nanoparticles using the catkin extract of Piper longum for bactericidal effect against food-borne pathogens via conventional and mathematical approaches

Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity

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