A Systematic Review on Pharmacological Activities of 4-Methylumbelliferon

Abstract

Umbelliferon, the natural crenelated coumarin distributed in the plants of a piaceae family, has shown various biological activities, especially as a cancer chemo preventive agent. Coumarins have been categorized as a member of family of benzo-pyrone, that consist of pyrone ring united to benzene ring. The benzo-pyrones may be sectioned to alfa type that coumarins belong and the gama type that flavonoids have been major members. Coumarins are chemical entity which has being synthesized in the past few years many forms of its derivatives; the entity provides the principal origin of motivating to numerous chemist to investigate its diverse medical efforts especially with regards to the anticoagulant activity. In present article we review recent 4-Methylumbelliferon, (4-MU) that are synthesized with it pharmacological activities antioxidant, anti-inflammatory, antimicrobial activity, ant hepatitis, hepatoprotective, anticancer, antipyretic and analgesic activity.

Synthesis, Bio-evaluation and Quantum Chemical Studies of Some Coumarin Derivatives

“…The antimicrobial properties of synthesized coumarins were examined on G+ bacterium species (Staphylococcus aurous and Streptococcus pyogenes) and G-bacteria species utilizing the diffusion technique [26]. (Pseudomonas aeruginosa and E. coli) as well as antifungal activities on Candida albicans.…”

“…Scheme 1 depicts the reaction pathway for the production of the compounds, commencing with 4-Methyl, 7-hydroxycoumarin. Coumarin derivatives have been produced by a number of researchers[20,[26][27][28][29].Reagents and Conditions: a= Methyl bromoacetate; b= Thiosiemacarbazide c= Terephthalaldehyde…”

Extending the Library of 4‐Hydroxycoumarin Derivatives with Potential Pharmacological Activity by a Catalyst‐Free and Purification‐Free Method

“…Commercialized anticoagulants namely warfarin, dicoumarol, and phenprocoumon that are branded under the name Coumadin , Acadyl , and Marcoumar , respectively, as well as the antibiotic novobiocin that is licensed under the trade name Albamycin are compounds [4] containing the 4‐hydroxycoumarin motif shown in Scheme 1. Besides this commercialized use of 4‐hydroxycoumarin derivatives, there have also been other evidence of bioactivity as antimicrobial and antifungal agents, [5,6] cancer chemotherapeutic agent, [7] intestinal anti‐ inflammatory agent [8] and other pharmaceutical agents as reported elsewhere [9] . Furthermore, there are also growing reports on exploration of 4‐hydroxycoumarin derivatives as ligands of metal complexes of rare earth elements [10] and transition metals [11–13] like neodymium (III), copper (II), and palladium (II) in Scheme 2, which demonstrate bioactivities in their own respect.…”

Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds

“…They play a major role in the proper functioning of the individual plant parts. Moreover, coumarin derivatives have gained considerable synthetic and pharmacological interest due to their various biological activities like antitumor, anti-HIV, antimicrobial, anti-cancer, serine protease inhibition, vasorelaxant and antioxidant activity [1,2,3,4,5].…”