A systematic review on different models of inducing obesity in animals: Advantages and limitations

Suleiman, Joseph Bagi; Mohamed, Mahaneem; Bakar, Ainul Bahiyah Abu

doi:10.5455/javar.2020.g399

Cited by 47 publications

(48 citation statements)

References 81 publications

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“…Rodent models have been an essential tool in the study of obesity. They are a convenient model for drug development and new dietary interventions [34]. However, when comparing with humans there are important limitations that must be considered.…”

Section: Animal Models Of Diet-induced Obesitymentioning

confidence: 99%

Dietary Options for Rodents in the Study of Obesity

2020

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Obesity and its associated metabolic diseases are currently a priority research area. The increase in global prevalence at different ages is having an enormous economic and health impact. Genetic and environmental factors play a crucial role in the development of obesity, and diet is one of the main factors that contributes directly to the obesogenic phenotype. Scientific evidence has shown that increased fat intake is associated with the increase in body weight that triggers obesity. Rodent animal models have been extremely useful in the study of obesity since weight gain can easily be induced with a high-fat diet. Here, we review the dietary patterns and physiological mechanisms involved in the dynamics of energy balance. We report the main dietary options for the study of obesity and the variables to consider in the use of a high-fat diet, and assess the progression of obesity and diet-induced thermogenesis.

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Section: Animal Models Of Diet-induced Obesitymentioning

confidence: 99%

Dietary Options for Rodents in the Study of Obesity

2020

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“…With the increasing comorbidities of hypertension and obesity (1,2), researchers have used a variety of animal models to mirror the association between obesity and hypertension in humans. Finding rat and mouse models that reproducibly exhibit both hypertension and obesity, typically stimulated through high-fat feeding, has not been straightforward (3,4). The Dahl salt-sensitive (SS) rat has been characterized as an adiposity-associated hypertension model (5,6).…”

Section: Introductionmentioning

confidence: 99%

Male and female high-fat diet-fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences

Watts

Darios

Contreras

et al. 2021

American Journal of Physiology-Heart and Circulatory Physiology

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Although the aorta exhibits medial hypertrophy in response to HF diet-induced hypertension, it did not exhibit hyperresponsive contraction to an α-adrenergic agonist nor endothelial cell dysfunction; this was true for both sexes. Unlike other hypertension models, PVAT around aorta from (male) rats on the HF diet retained significant anticontractile activity. PVAT around aorta of the male on a HF diet was modestly more fibrotic and lost the ability to assist in arterial stress relaxation.

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“…After this acclimatization period, mice were segregated in 7 groups ( n = 12) and randomly attributed one of the treatments as follows: Chow control force-fed daily with water (Chow, 3.1 kcal/g), HFHS diet providing 65% of energy from fat, force-fed daily with water (HFHS, 5.49 kcal/g), and a diet HFHS supplemented with one of the different products HMH1, HMH2, HMH3, HMH4, and HMH5 for the last five groups. Obesity was determined to be diet-induced, since this type of model best simulates aspects of the metabolic syndrome observed in humans [ 20 ]. The HFHS diet, often used in in vivo studies to induce obesity [ 21 , 22 , 23 ], was specifically selected to keep the same parameters as in the study by Durand et al [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model

Benoit

Dubois

Pilon

et al. 2021

Foods

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Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated in vivo at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation (p < 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation (p < 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity.

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A systematic review on different models of inducing obesity in animals: Advantages and limitations

Cited by 47 publications

References 81 publications

Dietary Options for Rodents in the Study of Obesity

Dietary Options for Rodents in the Study of Obesity

Male and female high-fat diet-fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences

Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model

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