A systematic review on antibiotics misuse in livestock and aquaculture and regulation implications in China

Shao, Yitian; Wang, Yiping; Yuan, Yujia; Xie, Yujing

doi:10.1016/j.scitotenv.2021.149205

Cited by 245 publications

(102 citation statements)

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“…The disease prevention or control is of great importance to keep the healthy fish fry stocks (Subasinghe et al, 2000), so antibiotics and insecticides were traditionally applied during fish fry breeding. However, the applications of antibiotics and insecticides have been seriously restricted in many countries, including China, because they are not only highly toxic to humans and fish and not easy to be degraded in the environment, but also lead to the potential development of antibiotic resistance (Holmström et al, 2003;Cabello, 2006;Zhou et al, 2019;Shao et al, 2021). Fish vaccine is of great potential in the prevention of disease outbreaks; however, only eight fish vaccines have been licensed in China, which is far more from enough to main the continual development of aquaculture production in China (Wang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…However, the diseases resulting from microorganism infection or other environmental factors during fish hatchery have threatened the production of larval loach (Shamsi et al, 2021). The applications of antibiotics and insecticides have been seriously restricted in many countries (Holmström et al, 2003;Cabello, 2006;Shao et al, 2021), while no specific fish vaccine nor mature vaccination route is available for fish fry (Rojo-Cebreros et al, 2018;Wang et al, 2020), which seriously restricts the stable fish fry stocks. In the present study, NaCl and H 2 O 2 were applied during loach egg hatching and the effects on the antioxidant capacity, immunity and lipid metabolism of fish larvae were evaluated as well as monitoring the early development-related genes.…”

Section: Introductionmentioning

confidence: 99%

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The Programming of Antioxidant Capacity, Immunity, and Lipid Metabolism in Dojo Loach (Misgurnus anguillicaudatus) Larvae Linked to Sodium Chloride and Hydrogen Peroxide Pre-treatment During Egg Hatching

Wang

Zou

et al. 2021

Front. Physiol.

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Non-nutritional stress during early life period has been reported to promote the metabolic programming in fish induced by nutritional stimulus. Sodium chloride (NaCl) and hydrogen peroxide (H2O2) have been widely applied during fish egg hatching, but the influences on health and metabolism of fish in their later life remain unknown. In the present study, H2O2 treatment at 400mg/L but not 200mg/L significantly increased the loach hatchability and decreased the egg mortality, while NaCl treatment at 1,000 and 3,000mg/L showed no significant influences on the loach hatchability nor egg mortality. Further studies indicated that 400mg/L H2O2 pre-treatment significantly enhanced the antioxidant capacity and the mRNA expression of genes involved in immune response of loach larvae, accompanied by the increased expression of genes involved in fish early development. However, the expression of most genes involved in lipid metabolism, including catabolism and anabolism of loach larvae, was significantly upregulated after 200mg/L H2O2 pre-treatment. NaCl pre-treatment also increased the expression of antioxidant enzymes; however, only the expression of C1q within the detected immune-related genes was upregulated in loach larvae. One thousand milligram per liter NaCl pre-treatment significantly increased the expression of LPL and genes involved in fish early development. Thus, our results suggested the programming roles of 400mg/L H2O2 pre-treatment during egg hatching in enhancing antioxidant capacity and immune response of fish larvae via promoting fish early development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Programming of Antioxidant Capacity, Immunity, and Lipid Metabolism in Dojo Loach (Misgurnus anguillicaudatus) Larvae Linked to Sodium Chloride and Hydrogen Peroxide Pre-treatment During Egg Hatching

Wang

Zou

et al. 2021

Front. Physiol.

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“…Currently, due to human demand for a variety of animal proteins, the aquaculture industry is developing rapidly (1). China has been one of the largest producers of aquatic products, and the coastal area is the main aquaculture base, including the coastal city of Zhanjiang (2).…”

Section: Introductionmentioning

confidence: 99%

“…China has been one of the largest producers of aquatic products, and the coastal area is the main aquaculture base, including the coastal city of Zhanjiang (2). Because of poor resistance and susceptibility to disease of aquatic animals, antibiotics are widely used in aquaculture to prevent and treat bacterial diseases (1). As a result, the residual antibiotics in aquatic products pose a potential risk to food safety, and antibiotics excreted from aquatic animals are dispersed in the water and sediments, thus leading to the emergence of drug-resistant bacteria and antimicrobial resistance (AMR) genes in aquaculture farms and the surrounding environment (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Escherichia coli also induces diseases in various aquatic animals, thereby causing serious economic losses for the aquaculture industry. In this context, the excessive use of antibacterial drugs in aquaculture has become inevitable, and aquaculture has become an important source of antibiotic-resistant strains and AMR genes of E. coli (1). However, the terrible thing is that the antibiotic-resistant bacteria can infect humans through the food chain or transfer AMR genes to human pathogens, leading to serious diseases such as meningitis, sepsis, and enterotoxemia in humans (12).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Resistance of Escherichia coli From Aquaculture Farms and Their Environment in Zhanjiang, China

et al. 2021

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Antimicrobial resistance (AMR) has become a major concern worldwide. To evaluate the AMR of Escherichia coli in aquaculture farms of Zhanjiang, China, a total of 90 samples from the water, soil, and sediment of three aquaculture farms (farms I, II, and III) in Zhanjiang were collected, and 90 strains of E. coli were isolated for drug resistance analysis and AMR gene detection. The results indicated that the isolated 90 strains of E. coli have high resistance rates to penicillin, amoxicillin, ampicillin, tetracycline, compound sulfamethoxazole, sulfisoxazole, chloramphenicol, florfenicol, and rifampin (≥70%). Among these antimicrobial drugs, the resistance rate to rifampicin is as high as 100%. Among the isolated 90 strains of E. coli, all of them were resistant to more than two kinds of antimicrobial drugs, the number of strains resistant to nine kinds of drugs was the largest (19 strains), and the most resistant strain showed resistance to 16 kinds of antibacterial drugs. Regarding the AMR genes, among the three aquaculture farms, the most resistance genes were detected in farm II (28 species). The detection rate of blaTEM, blaCIT, blaNDM, floR, OptrA, cmlA, aphA1, Sul2, oqxA, and qnrS in 90 isolates of E. coli was high (≥50%). The detection rate of carbapenem-resistant genes, such as blaKPC, blaIMP, and cfr, was relatively lower ( ≤ 30%), and the detection rate of mcr2 was the lowest (0). At least four AMR genes were detected for each strain, and 15 AMR genes were detected at most. Among them, the number of strains that carried 10 AMR genes was the largest (15 strains). Finally, a correlation analysis found that the AMR genes including blaTEM, blaCIT, floR, OptrA, cmlA, aac(3)-II, Sul2, ereA, ermB, oqxB, qnrA, mcr1, and mcr2 had a high correlation rate with drug resistance (≥50%). To summarize, the 90 strains of E. coli isolated from water, surrounding soil, and sediment samples showed resistance to multi-antimicrobial drugs and carried various antimicrobial resistance genes. Thus, it is essential to strengthen the rational use of antimicrobial drugs, especially the amide alcohol drugs, and control the AMR in the aquaculture industry of Zhanjiang, China.

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Sustainable agricultural practices contribute significantly to One Health

Yan

Xiong

Liu

et al. 2022

J of Sust Agri & Env

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The One Health concept proposes that the health of humans, animals, and the environment are interconnected. Agricultural production is a critical component of One Health as food links the environment to human health. Food not only provides nutrients to humans but also represents an important pathway for human exposure to environmental microbes as well as potentially harmful agrochemicals. In addition, inappropriate agronomic practices can cause damage to the environment which can have unintended adverse impacts on human health. Therefore, improving agricultural production systems and protecting environmental health should not be viewed as isolated goals as they are strongly interlinked. Here, we used the nexus of soil, plant, and human microbiomes to discuss sustainable agricultural production from the One Health perspective. We highlighted three interconnected challenges faced by current agronomic practices: the transmissions of pathogens in soil-human microbial loops, the dissemination of antibiotic resistance genes in agroecosystems, and the impacts of chemical pesticides on humans and environmental health. Finally, we propose the potential of utilising microbiomes for better sustainable agronomic practices to contribute to key goals of the One Health concept.

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A systematic review on antibiotics misuse in livestock and aquaculture and regulation implications in China

Cited by 245 publications

References 70 publications

The Programming of Antioxidant Capacity, Immunity, and Lipid Metabolism in Dojo Loach (Misgurnus anguillicaudatus) Larvae Linked to Sodium Chloride and Hydrogen Peroxide Pre-treatment During Egg Hatching

The Programming of Antioxidant Capacity, Immunity, and Lipid Metabolism in Dojo Loach (Misgurnus anguillicaudatus) Larvae Linked to Sodium Chloride and Hydrogen Peroxide Pre-treatment During Egg Hatching

Antimicrobial Resistance of Escherichia coli From Aquaculture Farms and Their Environment in Zhanjiang, China

Sustainable agricultural practices contribute significantly to One Health

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