A systematic review on antibacterial activity of zinc against Streptococcus mutans

Almoudi, Manal Mohamed; Hussein, Alaa Sabah; Hassan, Mohamed Ibrahim Abu; Zain, Nurhayati Mohamad

doi:10.1016/j.sdentj.2018.06.003

Cited by 119 publications

(74 citation statements)

References 34 publications

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“…Mouthwash containing zinc salts (zinc gluconate, zinc chloride) or ZnO NPs presents high anti-bacterial activity against S. mutans, in vitro [163,164]. ZnO NPs also act against Streptococcus sanguis known to be implied in caries and periodontal diseases [165].…”

Section: Zinc Oxide Nanoparticlesmentioning

confidence: 99%

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

et al. 2020

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Many investigations have pointed out widespread use of medical nanosystems in various domains of dentistry such as prevention, prognosis, care, tissue regeneration, and restoration. The progress of oral medicine nanosystems for individual prophylaxis is significant for ensuring bacterial symbiosis and high-quality oral health. Nanomaterials in oral cosmetics are used in toothpaste and other mouthwash to improve oral healthcare performance. These processes cover nanoparticles and nanoparticle-based materials, especially domains of application related to biofilm management in cariology and periodontology. Likewise, nanoparticles have been integrated in diverse cosmetic produces for the care of enamel remineralization and dental hypersensitivity. This review summarizes the indications and applications of several widely employed nanoparticles in oral cosmetics, and describes the potential clinical implementation of nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in the prevention of dental caries, hypersensitivity, and periodontitis.

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Section: Zinc Oxide Nanoparticlesmentioning

confidence: 99%

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

et al. 2020

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“…Zinc, due to its antibacterial property, can effectively be utilized in the commercial products like ointments, creams, lotions, and toothpastes. ZnO is generally considered as low toxic, but its nanoparticle form is highly reactive and responsive with high absorptivity (Almoudi et al 2018). Due to the unique piezoelectric, magnetic and optical properties, ZnO NPs have received tremendous attention and applied in many aspects of food and agriculture system (Emami-Karvani and Chehrazi 2011; Newton and Warburton 2007).…”

Section: Introductionmentioning

confidence: 99%

“…ZnO toxicological data obtained so far are inconsistent and conflicting. No reports are available which can clearly suggest actual concentration of ZnO NPs which can be harmful to human body (Almoudi et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress-mediated genotoxic effect of zinc oxide nanoparticles on Deinococcus radiodurans

2020

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Extensive use of nanomaterials in consumer products has invoked the concerns about interactions of nanoparticles with living organisms (including microorganisms). Zinc oxide nanoparticles (ZnO NPs) are well known for their antibacterial effect due to reactive oxygen species (ROS) generation. Therefore, their release into the environment is expected to raise major concern towards ecotoxicity. In the present study, we have studied the toxic effect of ZnO NPs on Deinococcus radiodurans, which is well known to show extraordinary resistant from the damaging effects of radiation. Result showed that ZnO NPs are significantly internalized into the bacterial cells and induce concentration-dependent toxicity with membrane damage. Genotoxicity studies revealed that ZnO exposure induces significant DNA damage to bacterial cells. All the observations evidenced that ZnO NPs induce significant ROS generation, protein oxidation and DNA damage with concomitant thiol depletion. Further, gene expression analysis showed that several DNA repair genes and metabolic pathway-related genes are downregulated upon ZnO NP exposure, with simultaneous increase in the expression of DNA damage response genes. Thus, the present study on toxicity of ZnO NPs on a model organism, D. radiodurans, inflicts the possible mechanism behind ZnO NP-mediated toxic effects on various other microbial organisms.

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“…Mutations in bacterial genes and multiple drug resistance (MDR) have raised challenges to treat MDR microorganisms because resistance drastically restricts therapeutic options and hence there is a need for effective antibacterial agents without adverse effects on treated cells. ZnO NPs are efficient multifunctional inorganic metal oxide NPs that have a wide energy gap of 3.37 eV with short wavelength and large exciton binding energy of 60 meV, is considered to be moderately toxic but is extremely reactive and sensitive with extreme absorbent potentiality [3]. ZnO NPs have been given considerable attention by varied applications in terms of their antimicrobial properties thereby reducing the problem of multi-drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Crotalaria verrucosa Leaf Extract Mediated Synthesis of Zinc Oxide Nanoparticles: Assessment of Antimicrobial and Anticancer Activity

et al. 2020

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In this work, we present an ecofriendly, non-hazardous, green synthesis of zinc oxide nanoparticles (ZnO NPs) by leaf extract of Crotalaria verrucosa (C. verrucosa). Total phenolic content, total flavonoid and total protein contents of C. verrucosa were determined. Further, synthesized ZnO NPs was characterized by UV–visible spectroscopy (UV-vis), X-ray diffractometer (XRD), Fourier transform infra-red (FTIR) Spectra, transmission electron microscope (TEM), and Dynamic light scattering (DLS) analysis. UV-vis shows peak at 375 nm which is unique to ZnO NPs. XRD analysis demonstrates the hexagonal phase structures of ZnO NPs. FTIR spectra demonstrates the molecules and bondings associated with the synthesized ZnO NPs and assures the role of phytochemical compounds of C. verrucosa in reduction and capping of ZnO NPs. TEM image exhibits that the prepared ZnO NPs is hexagonal shaped and in size ranged between 16 to 38 nm which is confirmed by DLS. Thermo-gravimetric analysis (TGA) was performed to determine the thermal stability of biosynthesized nanoparticles during calcination. The prepared ZnO NPs showed significant antibacterial potentiality against Gram-positive (S. aureus) and Gram-negative (Proteus vulgaris, Klebsiella pneumoniae, and Escherichia coli) pathogenic bacteria and SEM image shows the generalized mechanism of action in bacterial cell after NPs internalization. In addition, NPs are also found to be effective against the studied cancer cell lines for which cytotoxicity was assessed using MTT assay and results demonstrate highest growth of inhibition at the concentration of 100 µg/mL with IC50 value at 7.07 µg/mL for HeLa and 6.30 µg/mL for DU145 cell lines, in contrast to positive control (C. verrucosa leaf extract) with IC50 of 22.30 µg/mL on HeLa cells and 15.72 µg/mL on DU145 cells. Also, DAPI staining was performed in order to determine the effect on nuclear material due to ZnO NPs treatment in the studied cell lines taking leaf extract as positive control and untreated negative control for comparison. Cell migration assay was evaluated to determine the direct influence of NPs on metastasis that is potential suppression capacity of NPs to tumor cell migration. Outcome of the synthesized ZnO NPs using C. verrucosa shows antimicrobial activity against studied microbes, also cytotoxicity, apoptotic mediated DNA damage and antiproliferative potentiality in the studied carcinoma cells and hence, can be further used in biomedical, pharmaceutical and food processing industries as an effective antimicrobial and anti-cancerous agent.

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A systematic review on antibacterial activity of zinc against Streptococcus mutans

Abstract: This review indicated a significant growth inhibition effectiveness of zinc even at lower concentrations which indicate it's safely to be used in oral health products.

Cited by 119 publications

References 34 publications

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

Oxidative stress-mediated genotoxic effect of zinc oxide nanoparticles on Deinococcus radiodurans

Crotalaria verrucosa Leaf Extract Mediated Synthesis of Zinc Oxide Nanoparticles: Assessment of Antimicrobial and Anticancer Activity

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