A systematic review of Vaccine Breakthrough Infections by SARS-CoV-2 Delta Variant

Zhang, Mengxin; Liang, Ying; Yu, Dongsheng; Du, Bang; Cheng, Weyland; Li, Lifeng; Yu, Zhen; Luo, Shuang; Zhang, Yaodong; Wang, Huanmin; Zhang, Xianwei; Zhang, Wancun

doi:10.7150/ijbs.68973

Cited by 50 publications

(49 citation statements)

References 111 publications

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“…The additional mutations seen were L530M in ORF 1a, F3677L, P4715L, R5716C, I5967V and T6564I in ORF1b, T89I in ORF 3a and 203-204 del in N gene ( Figure 2 B). The mutations associated with immune evasion to antibody response elicited post infection or vaccination 9 were found in the breakthrough infection in this case. Similarly, the mutations which have been attributed to increase affinity binding between Receptor binding domain and ACE2 and those linked to immune evasion in Omicron 10 were found in the specimens collected during re-infection.…”

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confidence: 65%

A case of breakthrough infection with SARS-CoV-2 Delta derivative and reinfection with Omicron variant in a fully vaccinated health care professional

Pandit

Bhatt

Sahay

et al. 2022

Journal of Infection

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confidence: 65%

A case of breakthrough infection with SARS-CoV-2 Delta derivative and reinfection with Omicron variant in a fully vaccinated health care professional

Pandit

Bhatt

Sahay

et al. 2022

Journal of Infection

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“…A systematic review by Zhang et al determined that breakthrough cases rose from 1% of fully vaccinated people prior to the emergence of the Delta variant to 35% when it became the dominant circulating virus. Only 37% of the patients that met the criteria for being critically ill during hospitalization were fully vaccinated [ 17 ]. Waning vaccine efficacy over time likely contributed to the increased percentage of breakthrough cases [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

VSV-Based Vaccines Reduce Virus Shedding and Viral Load in Hamsters Infected with SARS-CoV-2 Variants of Concern

et al. 2022

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The continued progression of the COVID-19 pandemic can partly be attributed to the ability of SARS-CoV-2 to mutate and introduce new viral variants. Some of these variants with the potential to spread quickly and conquer the globe are termed variants of concern (VOC). The existing vaccines implemented on a global scale are based on the ancestral strain, which has resulted in increased numbers of breakthrough infections as these VOC have emerged. It is imperative to show protection against VOC infection with newly developed vaccines. Previously, we evaluated two vesicular stomatitis virus (VSV)-based vaccines expressing the SARS-CoV-2 spike protein alone (VSV-SARS2) or in combination with the Ebola virus glycoprotein (VSV-SARS2-EBOV) and demonstrated their fast-acting potential. Here, we prolonged the time to challenge; we vaccinated hamsters intranasally (IN) or intramuscularly 28 days prior to infection with three SARS-CoV-2 VOC—the Alpha, Beta, and Delta variants. IN vaccination with either the VSV-SARS2 or VSV-SARS2-EBOV resulted in the highest protective efficacy as demonstrated by decreased virus shedding and lung viral load of vaccinated hamsters. Histopathologic analysis of the lungs revealed the least amount of lung damage in the IN-vaccinated animals regardless of the challenge virus. This data demonstrates the ability of a VSV-based vaccine to not only protect from disease caused by SARS-CoV-2 VOC but also reduce viral shedding.

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“…According to the World Health Organization (WHO), with the rise of the Delta and Omicron variants [ 1 ], the number of global confirmed cases approached 300 million with 5.5 million deaths at the beginning of 2022 [ 2 ]. Large-scale vaccination has become one of the most important public health policies for countries to prevent the spread of COVID-19; however, breakthrough infections caused by the variants confirm that high vaccine coverage may not guarantee effective control of the spread of COVID-19 [ 3 , 4 ]. In other words, vaccination is not the only reliable way to control the pandemic, as the implementation of epidemic prevention and control measures cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude, and Practice (KAP) toward COVID-19 Pandemic among the Public in Taiwan: A Cross-Sectional Study

Luo

Chen

Yang

et al. 2022

IJERPH

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Purpose: Knowledge, attitude, and practice (KAP) models are often used by researchers in the field of public health to explore people’s healthy behaviors. Therefore, this study mainly explored the relationships among participants’ sociodemographic status, COVID-19 knowledge, affective attitudes, and preventive behaviors. Method: This study adopted an online survey, involving a total of 136 males and 204 females, and used a cross-sectional study to investigate the relationships between variables including gender, age, COVID-19 knowledge, positive affective attitudes (emotional wellbeing, psychological wellbeing, and social wellbeing), negative affective attitudes (negative self-perception and negative perceptions of life), and preventive behaviors (hygiene habits, reducing public activities, and helping others to prevent the epidemic). Results: The majority of participants in the study were knowledgeable about COVID-19. The mean COVID-19 knowledge score was 12.86 (SD = 1.34, range: 7–15 with a full score of 15), indicating a high level of knowledge. However, the key to decide whether participants adopt COVID-19 preventive behaviors was mainly their affective attitudes, especially positive affective attitudes (β = 0.18–0.25, p< 0.01), rather than COVID-19 disease knowledge (β = −0.01–0.08, p > 0.05). In addition, the sociodemographic status of the participants revealed obvious differences in the preventive behaviors; females had better preventive behaviors than males such as cooperating with the epidemic prevention hygiene habits (t = −5.08, p< 0.01), reducing public activities (t = −3.00, p< 0.01), and helping others to prevent the epidemic (t = −1.97, p< 0.05), while the older participants were more inclined to adopt preventive behaviors including epidemic prevention hygiene habits (β = 0.18, p = 0.001, R2 = 0.03), reducing public activities (β = 0.35, p< 0.001, R2 = 0.13), and helping others to prevent the epidemic (β = 0.27, p< 0.001, R2 = 0.07). Conclusions: Having adequate COVID-19 knowledge was not linked to higher involvement in precautionary behaviors. Attitudes toward COVID-19 may play a more critical function in prompting individuals to undertake preventive behaviors, and different positive affective attitudes had different predictive relationships with preventive behaviors.

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A systematic review of Vaccine Breakthrough Infections by SARS-CoV-2 Delta Variant

Cited by 50 publications

References 111 publications

A case of breakthrough infection with SARS-CoV-2 Delta derivative and reinfection with Omicron variant in a fully vaccinated health care professional

A case of breakthrough infection with SARS-CoV-2 Delta derivative and reinfection with Omicron variant in a fully vaccinated health care professional

VSV-Based Vaccines Reduce Virus Shedding and Viral Load in Hamsters Infected with SARS-CoV-2 Variants of Concern

Knowledge, Attitude, and Practice (KAP) toward COVID-19 Pandemic among the Public in Taiwan: A Cross-Sectional Study

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