A Systematic Review of Treatment Modalities for Primary Basal Cell Carcinomas

An Overview on Basal Cell Carcinoma

“…(74) two freeze-thaw cycles of 30 s each are still recommended in the treatment of facial BCC. A systematic review of recurrence rates of studies ( ≥ 50 patients) published between 1970 and 1997 indicated that cryotherapy in the treatment of primary BCC resulted in a cumulative 5-year recurrence rate of 4% to 17% (81). For treatment of recurrent BCC, the recurrence rate has ranged from 4% (for 56 tumors) to 12% (for 164 tumors), with variable follow-up periods reported (82,83).…”

“…However, effective clearance of BCC tumors with surgical procedures is highly dependent on tumor margins and the skill of the healthcare provider. Thissen et al (81) recommend that surgical excision is preferred over common procedures such as cryosurgery and ED & C, provided surgery is not contraindicated. With PDT, there is limited tissue penetration (i.e.…”

“…depth), a critical requirement when treating invasive tumors. Mohs micrographic surgery is recommended for larger BCC tumors in high-risk areas of the face and head and for tumors with aggressive growth patterns (81).…”

Immunocryosurgery for patients with therapeutically challenging basal cell carcinomas: Report of two representative cases

“…Surgery, including Mohs' technique, is regarded the reference modality for the treatment of most basal cell carcinomas (BCCs) (1). Yet surgical treatment in challenging cases (large, multiple, confluent or recurrent BCCs) can be an arduous undertaking with relatively high relapse rates, particularly when conventional surgery is employed.…”

Defect Reconstruction of the Nose After Surgery for Nonmelanoma Skin Cancer: Our Clinical Experience

“…Primary treatment for NMSC is surgery; however, some effective nonsurgical methods also exist (7)(8)(9)(10). The primary aim of surgery is adequate resection of the tumor, while the secondary aim is reconstruction of the defect (11).…”